Patients and controls
The study encompassed 124 patients, who were categorized into four distinct groups, comprising 37 individuals in the CIS-CIS group (consisting of 7 males and 30 females, with a mean age of 34.0), 14 patients in the CIS-RRMS group (comprising 2 males and 12 females, with a mean age of 35.0), 18 patients in the RRMS group (comprising 4 males and 14 females, with a mean age of 38.0), and 55 individuals in the control group (CG) (comprising 9 males and 46 females, with a mean age of 33.0). These groups exhibited homogeneity with regard to both gender and age. Detailed data is presented in Figures 1 and 2.
All patients underwent examinations for CXCL13, IL-8, cerebrospinal fluid (CSF) cell count, qualitative CSF cytology, oligoclonal bands (OCB) of IgG, and the Expanded Disability Status Scale (EDSS). A summary of the data is presented in Figures 3 and 4 . At the time of collection, patients exhibited no clinical or laboratory indications of neuroinfection, and there were no ongoing systemic inflammatory processes.