Group comparison
Following the statistical analysis, markedly elevated levels of IL-8 were observed in all examined patient groups when compared to the control group (CIS-CIS: median 51.40 pg/ml vs. 36.60 pg/ml; CIS-RRMS: median 55.85 pg/ml vs. 36.60 pg/ml; RRMS: 55.70 pg/ml vs. 36.60 pg/ml; p < 0.0001, Kruskal-Wallis test). No statistically significant distinctions were noted among the individual patient groups, as the levels of IL-8 in these groups were comparable, as illustrated inBox Plot 1 . A summary of the data is presented inFigure 3 .
Significantly elevated levels of the CXCL13 marker were also observed in all groups when compared to the control group (CIS-CIS: median 16.82 pg/ml vs. 0.10 pg/ml; CIS-RRMS: median 32.30 pg/ml vs. 0.10 pg/ml; RRMS: median 5.37 pg/ml vs. 0.10 pg/ml; p < 0.0001, Kruskal-Wallis test). Notably, within the CIS-RRMS group, the concentration of CXCL13 was higher in comparison to the other groups (CIS-CIS median 16.82 pg/ml; CIS-RRMS median 32.30 pg/ml; RRMS median 5.37 pg/ml). However, these differences did not attain statistical significance, as indicated by Box Plot 2 . A summary of the data is presented inFigure 3 .