Patients and controls
The study encompassed 124 patients, who were categorized into four
distinct groups, comprising 37 individuals in the CIS-CIS group
(consisting of 7 males and 30 females, with a mean age of 34.0), 14
patients in the CIS-RRMS group (comprising 2 males and 12 females, with
a mean age of 35.0), 18 patients in the RRMS group (comprising 4 males
and 14 females, with a mean age of 38.0), and 55 individuals in the
control group (CG) (comprising 9 males and 46 females, with a mean age
of 33.0). These groups exhibited homogeneity with regard to both gender
and age. Detailed data is presented in Figures 1 and 2.
All patients underwent examinations for CXCL13, IL-8, cerebrospinal
fluid (CSF) cell count, qualitative CSF cytology, oligoclonal bands
(OCB) of IgG, and the Expanded Disability Status Scale (EDSS). A summary
of the data is presented in Figures 3 and 4 . At the time of
collection, patients exhibited no clinical or laboratory indications of
neuroinfection, and there were no ongoing systemic inflammatory
processes.