Trials monitoring skin microbiota changes in response to treatment |
Trials monitoring skin microbiota changes in response to treatment |
Trials monitoring skin microbiota changes in response to treatment |
Trials monitoring skin microbiota changes in response to treatment |
Trials monitoring skin microbiota changes in response to
treatment |
NCT01597817
|
Efficacy and Safety of a Biofunctional Textile in the Management of
Atopic Dermatitis
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Subjects above 12 years of age with atopic dermatitis
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Randomized blinded controlled trial
Intervention: chitosan coated textile (cotton long sleeved shirts and
pants)
Comparator: chitosan-free cotton long sleeved t-shirts and pants.
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SCORAD
Quality of Life
Eczema symptoms
Eczema treatment
Immunological markers
Skin microbiota (S. aureus)
Genetic mutations
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NCT01631617
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Effects of Treatments on Atopic Dermatitis
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Cohort 3: subjects 2 – 50 years of age with atopic dermatitis and
symptoms of active bacterial infection
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Randomized blinded controlled trial
Intervention: Cephalexin with dilute bleach bath
Comparator: Cephalexin with placebo bath
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Difference in Shannon Diversity Indices (SDI) from baseline to day 14
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NCT03376243
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EARLYEMOLLIENT - Feasibility of Early Emollient Use in Children With
Atopic Eczema
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50 high-risk neonates from day 1- 21 of life
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Pragmatic, parallel group, assessor-blind randomised open-label
prospective study Intervention: LIPIKAR BAUME AP+ emollient
Comparator: Structured parent education
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Willingness to participate
Cumulative incidence of eczema
TEWL
Microbiome diversity over time
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NCT03673059
|
Clinical Trial to Assess the Effects of Topical Lotions on Changes in
the Skin Microbiome and Associations With Itch
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Subjects 16-50 years of age with mild to moderate eczema with recent
flare
|
Randomized blinded controlled trial
Intervention: Cosmetic Moisturizer Regimen
DRUG: OTC Eczema Moisturizer
|
microbiome composition
pH changes
TEWL
Skin hydration
EASI score
ADSI score
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NCT04800185
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Characterizing Skin Microbiome Change in Atopic Dermatitis
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Patients 2 years and above with atopic dermatitis
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Open label trial
DRUG: Crisaborole 2% topical ointment
Comparator: None
|
Skin microbiome before, during and after treatment with crisaborole
2% ointment
|
NCT05523986
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Vitamin D Treatment Effect for Atopic Dermatitis in Children
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Children 1-18 years with moderate to severe AD
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Randomized controlled trial
Intervention: Vitamin D (2000IU/day) for 6 months
Comparator: Placebo
|
Vitamin D levels
Genotyping
Nasal, skin and anal microbiota composition
Total and antigen-specific IgE
EASI
POEM
|
NCT03614221
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Comparison of Lindioil (Indigo Naturalis Oil Extract) Ointment to
Protopic® Ointment 0.1% in Treating Atopic Dermatitis
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Patients 16 – 65 years with atopic dermatitis
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Randomized cross-over trial
Intevention: Lindioil ointment
Comparator: Protopic 0.1% ointment
|
EASI-50, EASI-75, EASI-90
Investigator’s Global Assessment (IGA)
Body surface area of involvement
Length of relapse-free days after treatment cessation
Pruritus symptoms
Quality of life
Skin microbiome changes
|
NCT05688735
|
Assessment of the Effect of Coconut and Sunflower Seed Oil Derived
Isosorbide Diesters and Colloidal Oatmeal
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Children 2 – 17 years with active atopic dermatitis
|
Randomized blinded controlled trial
Intervention: Isosorbide Diester (0.1% colloidal oatmeal) + topical
hydrocortisone 2.5% ointment
Comparator: Placebo vehicle (with 0.1% colloidal oatmeal) + topical
hydrocortisone 2.5% ointment
|
EASI
Itch symptoms
Topical steroid use
TEWL
Skin hydration
Change in S. aureus abundance on skin
|
Trials on Microbiota-based interventions |
Trials on Microbiota-based
interventions |
Trials on Microbiota-based interventions |
Trials on
Microbiota-based interventions |
Trials on Microbiota-based
interventions |
NCT04265716
|
Topical L. reuteri in Children With Atopic Dermatitis
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Children 1 – 18 years of age with atopic dermatitis
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Intervention: Topical probiotic L. reuteri
Comparator: standard of care + placebo
|
Improvement in skin appearance
SCORAD at 16 weeks
|
NCT04771910
|
Study of the Skin Microbiome and the Potential of a Topical Probiotic
Cream for Atopic Dermatitis
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Patients with atopic dermatitis
|
Randomized controlled trial
Intervention: Topical cream with live probiotic (Lactobacillus)
Comparator: placebo cream
|
Skin microbiome composition
EASI
Skin itch symptoms
|
NCT03928431
|
Restoration of Microbiota in Neonates
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Infants of healthy mothers with uncomplicated pregnancies at term
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Randomized controlled trial
Intervention: swab from maternal vagina + fecal swab on Caesarean-born
infants’ skin
Comparator: clean saline-soaked gauze
|
IgE-associated allergic disease at 2 years of age
Immunological markers
Microbial composition between groups
|