NCT Number Study Title Subjects Interventions Outcome Measures
Trials monitoring skin microbiota changes in response to treatment Trials monitoring skin microbiota changes in response to treatment Trials monitoring skin microbiota changes in response to treatment Trials monitoring skin microbiota changes in response to treatment Trials monitoring skin microbiota changes in response to treatment
NCT01597817
Efficacy and Safety of a Biofunctional Textile in the Management of Atopic Dermatitis
Subjects above 12 years of age with atopic dermatitis
Randomized blinded controlled trial Intervention: chitosan coated textile (cotton long sleeved shirts and pants) Comparator: chitosan-free cotton long sleeved t-shirts and pants. SCORAD Quality of Life Eczema symptoms Eczema treatment Immunological markers Skin microbiota (S. aureus) Genetic mutations
NCT01631617
Effects of Treatments on Atopic Dermatitis
Cohort 3: subjects 2 – 50 years of age with atopic dermatitis and symptoms of active bacterial infection
Randomized blinded controlled trial Intervention: Cephalexin with dilute bleach bath Comparator: Cephalexin with placebo bath Difference in Shannon Diversity Indices (SDI) from baseline to day 14
NCT03376243
EARLYEMOLLIENT - Feasibility of Early Emollient Use in Children With Atopic Eczema
50 high-risk neonates from day 1- 21 of life
Pragmatic, parallel group, assessor-blind randomised open-label prospective study Intervention: LIPIKAR BAUME AP+ emollient Comparator: Structured parent education Willingness to participate Cumulative incidence of eczema TEWL Microbiome diversity over time
NCT03673059
Clinical Trial to Assess the Effects of Topical Lotions on Changes in the Skin Microbiome and Associations With Itch
Subjects 16-50 years of age with mild to moderate eczema with recent flare
Randomized blinded controlled trial Intervention: Cosmetic Moisturizer Regimen DRUG: OTC Eczema Moisturizer microbiome composition pH changes TEWL Skin hydration EASI score ADSI score
NCT04800185
Characterizing Skin Microbiome Change in Atopic Dermatitis
Patients 2 years and above with atopic dermatitis
Open label trial DRUG: Crisaborole 2% topical ointment Comparator: None Skin microbiome before, during and after treatment with crisaborole 2% ointment
NCT05523986
Vitamin D Treatment Effect for Atopic Dermatitis in Children
Children 1-18 years with moderate to severe AD
Randomized controlled trial Intervention: Vitamin D (2000IU/day) for 6 months Comparator: Placebo Vitamin D levels Genotyping Nasal, skin and anal microbiota composition Total and antigen-specific IgE EASI POEM
NCT03614221
Comparison of Lindioil (Indigo Naturalis Oil Extract) Ointment to Protopic® Ointment 0.1% in Treating Atopic Dermatitis
Patients 16 – 65 years with atopic dermatitis
Randomized cross-over trial Intevention: Lindioil ointment Comparator: Protopic 0.1% ointment EASI-50, EASI-75, EASI-90 Investigator’s Global Assessment (IGA) Body surface area of involvement Length of relapse-free days after treatment cessation Pruritus symptoms Quality of life Skin microbiome changes
NCT05688735
Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diesters and Colloidal Oatmeal
Children 2 – 17 years with active atopic dermatitis
Randomized blinded controlled trial Intervention: Isosorbide Diester (0.1% colloidal oatmeal) + topical hydrocortisone 2.5% ointment Comparator: Placebo vehicle (with 0.1% colloidal oatmeal) + topical hydrocortisone 2.5% ointment EASI Itch symptoms Topical steroid use TEWL Skin hydration Change in S. aureus abundance on skin
Trials on Microbiota-based interventions Trials on Microbiota-based interventions Trials on Microbiota-based interventions Trials on Microbiota-based interventions Trials on Microbiota-based interventions
NCT04265716
Topical L. reuteri in Children With Atopic Dermatitis
Children 1 – 18 years of age with atopic dermatitis
Intervention: Topical probiotic L. reuteri Comparator: standard of care + placebo Improvement in skin appearance SCORAD at 16 weeks
NCT04771910
Study of the Skin Microbiome and the Potential of a Topical Probiotic Cream for Atopic Dermatitis
Patients with atopic dermatitis
Randomized controlled trial Intervention: Topical cream with live probiotic (Lactobacillus) Comparator: placebo cream Skin microbiome composition EASI Skin itch symptoms
NCT03928431
Restoration of Microbiota in Neonates
Infants of healthy mothers with uncomplicated pregnancies at term
Randomized controlled trial Intervention: swab from maternal vagina + fecal swab on Caesarean-born infants’ skin Comparator: clean saline-soaked gauze IgE-associated allergic disease at 2 years of age Immunological markers Microbial composition between groups