Fig.6 Photothermal effect and E2 release behavior of bilayer scaffolds. (A) Temperature changes of S+F and S+F-PDA@E2 bilayer scaffolds under the irradiation of an 808 nm NIR laser at different energy densities (0.5 and 1.0 W/cm2). (B) Infrared thermal images of S+F and S+F-PDA@E2 bilayer scaffolds after a 3-min NIR laser irradiation. (C) In vitro E2 cumulative release curves of S+F-PDA@E2 bilayer scaffolds with (0.5 and 1.0 W/cm2, respectively) or without NIR irradiation (pH 7.4). (D) In vitroE2 cumulative release curves of S+F-PDA@E2 bilayer scaffolds in pH 4.5, 7.4, and 9.0 solutions, respectively.