A Key Clinical Message:
Our case reported a 22 years old male presented with headache, and sudden vision loss, ten days after receiving the first dose of COVID-19 vaccination. Counting fingers in both eyes was his visual acuity on examination and bilateral optic disc edema on fundscopy was found. Brain MRI was normal. After methylprednisolone pulse therapy, plasmapheresis, and IV cyclophosphamide courses, the optic disc edema disappeared, and his visual function did not improve. Reported cases of optic neuritis develop after mRNA COVID-19 vaccination are limited.