Abstract
Introduction: Coexistence of scleroderma with multiple myeloma
is an unusual finding with unclear significance. Only 15 cases of MM
with scleroderma have been reported until now.
Case presentation : We report a case of a 58-year-old female
with 10-year history sceroderma, complaining from pallor and fatigue.
The initial workup showed a normocytic anemia with elevated ESR and
total proteins. On fruther investigation the gamma globulines were also
high and the bone marrow biopsy showed interstitial and focal increase
in plasma cells without bone marrow fibrosis. Skeletal survey showed
osteopenia, but no osteolytic lesion or fracture. The patient was
diagnosed as scleroderma with coexistence of immunoglobulin G (IgG) ,
kappa (κ) MM.
Conclusion: In view of the possible coexistence of scleroderma
with MM, it is suggested that all patients with scleroderma should be
screened for monoclonal gammopathy and MM regarding their age. future
studies should be directed to determine the exact mechanism of these two
conditions association and the effect of MM treatment on SSc
improvement.
Keywords : Systemic Sclerosis (SSc),Multiple Myeloma ( MM),
Osteolytic lesion, Immunoglobulin G, κ MM