No. Chinese medicines and formulae Level Mechanism on oxidative stress Mechanism on inflammation reference
1 Angong Niuhuang Pill (Formula) A,B2 induced ApoE-/- mice early and mid-term AS model via regulating Th17/Treg balance, inhibiting chronic inflammation, reducing plaque collagen fibers, and reducing inflammatory cells infiltration, to exert its multi-channel multi-target anti-early and mid-term AS effects Fan et al., 2020
2 Bazi Bushen capsule (Formula) A,B2 GPER1-dependent anti-inflammatory and anti-apoptotic mechanisms Huang et al., 2021
3 Bushen Jiangzhi formula (Formula) B2 regulating the expression of autophagy-related proteins LC3, Beclin 1, and p62, Cao et al., 2020
4 Bushen Kangshuai Tablet (Formula) B3 suppress the inflammation reaction in rabbits to prevent AS formation Zhang et al., 2009
5 Buyang Huanwu decoction (Formula) B2 promote revascularization on db/db mice with HLI through targeting antioxidation, anti-inflammation, and angiogenesis via the AKT/GSK3β/NRF2 pathway. Bao et al., 2021
6 BuYangHuanWu decoction (Formula) B1 inflammatory cytokines were suppressed and that the NF-κB signaling pathway Liu et al., 2019
7 Cardiotonic pills (Formula) B2 downregulation of plasma macrophage inflammatory protein-1α and intercellular cell adhesion molecule-1. Deng et al., 2019
8 Chaihu-Shugan-San (Formula) A,B2 regulation of proinflammatory factors and BDNF-TrkB signaling Li et al., 2019
9 Compound Danshen tablet (Formula) B2 reduced the levels of the oxidative damage molecule 4-HNE reduced the levels of the inflammatory factor ICAM-1 Guo et al., 2021
10 Danggui Buxue Decoction (Formula) C improvement of extracellular matrix (ECM) deposition in the blood vessel wall and the anti-vascular local inflammatory response Xu et al., 2021
11 Danhong injection (Formula) B2 attenuation of lipopolysaccharide-induced expression of TNF-α, IL-1β, IL-6 in macrophages Chen et al., 2014
12 Dan-Lou prescription (Formula) A effectively attenuated macrophage foam cell formation via the TLR4/NF-κB and PPARγ signaling pathways Gao et al., 2018
13 Danshen-shanzha(Formula) B2 decreased the concentrations of interleukin (IL)-1β and IL-18 Zhang et al., 2019
14 Danlou tablet (Formula) B2 regulating the NF-κB signaling pathway. Gao et al., 2020
15 Danlou tablet (Formula) B2 suppressing NF-κB signaling and triggering PPARα/ABCA1 signaling pathway Hao et al., 2019
16 Dingxin recipe (Formula) A,B2 downregulation of TNF-α, IL-6, ICAM-1 and VCAM-1 through mitogen-activated protein kinase pathways Cui et al., 2020
17 Formula of removing both phlegm and blood stasis (Formula) B (Pig) controlling NF-kappaB p65 nuclear translocation Ren et al., 2014
18 Fufang-Zhenzhu-Tiaozhi Capsule (Formula) B3 activation of APN signaling pathway Li et al., 2020
19 Guanxinkang (Formula) B2 regulating PPARγ, LXRα and ABCA1 interactions in the ApoE-knockout mice Mao et al., 2012
20 Guanxinkang decoction (Formula) A,B2 efferocytosis and MAPKs signaling pathways in LDLR-/- mice and RAW264.7 cells Zhang et al., 2021
21 Guanxinshutong capsule (Formula) A reduced the activity of oxidative parameter MDA and upregulated the activities of antioxidant enzymes (SOD and GSH) modulated lipid profile, downregulated the level of inflammatory cytokines and NF-κBp65. Lu et al., 2020
22 Huotan Jiedu Tongluo (Formula) B3 inhibition of BH4/eNOS uncoupling and the reduction of oxidative stress Li et al., 2018
23 Hwangryunhaedok-tang (Formula) A modulating LDL oxidation and VSMC proliferation Seo et al., 2015
24 Jianpi Huazhuo Tiaozhi granules (Formula) A inhibiting the NOX/ROS-NF-κB pathway. Liu et al., 2020
25 Kangshuanyihao formula (Formula) B1 regulating the SIRT1/TLR4/NF-κB signaling pathway Han et al., 2017
26 modified Yuejuwan (Formula) A Inhibiting the Activity of the TRIM37/TRAF2/NF- κ B Pathway Gui et al., 2022
27 Rongban Tongmai granule (Formula) B3 prevent atherosclerosis by antioxidative stress and correcting unbalance of redox. Lin et al., 2011
28 Shen-Hong-Tong-Luo formula (Formula) A,B2 activating the PPAR-γ/LXR-α/ABCA1 pathway Zhang et al., 2020
29 Shenmai formula (Formula) A suppress the NF-κB p65 expression and IκBα phosphorylation Zhu et al., 2017
30 Shen-Yuan-Dan Capsule (Formula) A,B2 up-regulated Beclin1 and LC3II/I proteins inhibited AKT phosphorylation at Ser473 and mTOR phosphorylation Zhou et al., 2019
31 Shexiang Baoxin Pill (Formula) B2 the level elevation of Mfn2 and reduced phosphorylation of p38, JNK, and NF-κB., reduced the level of SR-A and LOX-1 and elevated the content of LXRα, ABCA1, and ABCG1 in the arterial wall Lu et al., 2019
32 Shexiang Tongxin dropping (Formula) B1 the levels of pro-inflammatory cytokines including IL-2, IL-6, TNF-α and γ-IFN were markedly reduced Xiong et al., 2015
33 Shenlian extract A,B (Dog) NF-κB signaling pathway Guo et al., 2020
34 Sobokchukeo-Tang (Formula) C inhibited TNF‑α and IL‑6 Lee et al., 2017
35 Suxiao Jiuxin Pill (Formula) B1 elevate the activity of serum SOD, decrease serum level of MDA and ox-LDL, and reduce the expression of PPARgamma and NF-kappaB proteins L i et al., 2011
36 Taoren Honghua drug (Formula) A,B2 MAPKs, ERK5/STAT3, and AKT/NF-κB p65 signaling pathways Wang et al., 2020
37 The Angong Niuhuang Pill (Formula) B1 decreased aortic membrane thickness, the maximum platelet aggregation rates, and the ratio of low density lipoprotein cholesterol (LDL) to high density lipoprotein cholesterol (HDL) Fu et al., 2017
38 Tiaogan-Liqi prescription (Formula) A,B2 reduce plasma lipid profiles and plasma inflammatory cytokines, reduce intracellular lipid accumulation, suppress the production of inflammatory cytokines of macrophages induced by oxidized-LDL, and inhibit the protein expression of heat shock protein 90 and toll-like receptor 4 Chen et al., 2021
39 Tiaopi Huxin recipe (Formula) A,B2 decreased expression of caveolin-1 and NF-κB Wen et al., 2019
40 Tongxinluo (Formula) A,B2 inhibiting the expression of p22(phox), p47(phox) and HO-1 inhibiting the expression and activation of NF-κB Wu et al., 2015
41 Tongxinluo (Formula) B1 reducing expression of inflammatory cytokine MCP-1 and ICAM-1 Yao et al., 2014
42 Tongxinluo (Formula) A,B2 Suppression of miR-155 expression mediated by Akt1 and blockade of the feedback loop between miR-155 and TNF-α are important pathways whereby Zhang et al., 2014
43 Tongxinluo (Formula) B3 inhibit the NLRP3 inflammatory pathway Qi et al., 2022
44 Tongxinluo capsule (Formula) B2 The comprehensive mechanisms, in addition to inflammation and lipid metabolism, might also involve cell physical function, hormone secretion, protein binding, and immune response process. Ma et al., 2019
45 Xiao-Zhi formula (Formula) A,B2 promotes lipid efflux and inhibits macrophage-mediated inflammation, producing a therapeutic effect against atherosclerosis Li et al., 2021
46 Xin-mai-jia (Formula) A,B1 reduced NO levels and increased ROS productions Yin et al., 2017
47 Yangyin Qingre Huoxue Prescription (Formula) A,B2 Suppressed IL-6-p-STAT3 signaling and restored IL-2-p-STAT5 signaling in the presence of YQHP may partake in the regulation of Th17 and Treg differentiation. Moreover, YQHP modulated transcriptional levels of costimulator CD80 in aortas as well corresponding to the downregulation of GM-CSF in serum and CD3 expression in CD4+ T cells Qiu et al., 2019
48 Yindanxinnaotong (Formula) B1 inhibiting the nuclear factor-kappa B signal pathway Cheng et al., 2015
49 Yiqi-Huoxue granule (Formula) A regulating the KLF2 expression and NF-κB signaling pathway Wu et al., 2019
50 Yirui capsules (Formula) B2 reduces the atherosclerotic plaque burden, thereby alleviating AS by modulating the lipid profile and inhibiting inflammation Xu et al., 2018
51 Zhixiong Capsule (Formula) B1 IL-4, IL-13, MAPK1, MAPK14, JUN and P53 were confirmed as key targets Zhai et al., 2019
52 Zhizi Chuanxiong Capsule (Formula) B3 treat AS through regulating the abnormal hypermethylated and hypomethylated genes in AS rabbit model. Zhou et al., 2018
53 Dendrobium catenatum Lindl. B (Zebrafish) alleviate the lipid metabolism disorder, oxidative stress, and inflammation to reduce the plaque formation of AS zebrafish larval model. Han et al., 2021
54 Fermentum Rubrum B2 reduced the protein levels of NF-κB and MMP-9 of the aorta Wu et al., 2017
55 Ginkgo biloba B2 inhibition of mTOR Tian et al., 2019
56 Hirudo nipponica A regulating the LOX-1/LXR-α/ABCA1 pathway Lu et al., 2019
57 Patrinia villosa Juss., Patrinia scabiosaefolia Fisch. B2 reversing lysophosphatidylcholine (LPC) in the glycerophospholipid metabolic pathway Su et al., 2022
58 Pueraria lobata A protected HUVECs against rotenone-induced oxidative stress and apoptosis Gao et al., 2016
59 Salvia miltiorrhiza A induced HO-1 expression through PI3K/Akt-MEK1-Nrf2 pathway and reduced intracellular production of reactive oxygen species via induction of HO-1 expression Lee et al., 2012
60 Schisandra chinensis B1 reduced the malondialdehyde levels (72.5, 69.3, 67.3%), and up-regulated the Nrf-2 and HO-1 expression (p < 0.05). Chen et al., 2018
61 Usnea diffracta Vain. B1 promoting the expression of serum IL-10 and inhibition of TLR5/NF-κB signaling pathway. Zhao et al., 2019
62 Astragali Radix, Coptis Rhizoma C M1/M2 and Th1/Th2 immune balance Li et al., 2022
Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology. Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology. Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology. Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology. Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology. Notes: In Level, A represents in vitro; B represents in vivo; B1 represents rats; B2 represents mice; B3 represents rabbit; C represents network pharmacology.