Statistical analysis
Baseline characteristics were shown in continuous data presented as
medians and categorical data were presented as numbers. Comparisons
between groups were performed using Fisher’s exact test for categorical
variables and Wilcoxon rank-sum test for continuous variables. The
annualized rate of reactions was calculated by summing the number of
reactions per patient and dividing it by the year. Logistic regression
was used to perform univariate and multivariate analyses. The factors
significantly associated with AAR were assessed for a crude odds ratio
(OR) or an adjusted OR (aOR), with corresponding 95% confidence
interval (CI) and associated p -values. Statistical significance
was set at p < .05. All data were processed and
summarized using GraphPad Prism 7 for Mac (La Jolla, CA, USA) and IBM
SPSS Statistics for Windows (version 24.0; IBM Corp., Armonk, NY, USA).
Logistic regression analyses were performed to assess risk factors for
AAR. In the univariate logistic regression analysis, all patient
characteristic variables at baseline were used. In the multiple logistic
regression analysis, variables with p <0.1 in the
univariate analysis were adjusted.