Risk factors for AAR
The results of the univariate analysis for the overall cohort and HE,
CM, wheat, and peanut allergy sub-cohorts are shown in Supplementary
Tables S4A and S4B, respectively. In multiple logistic regression
analysis, the significant risk factor for AAR was low-dose reactivity
(aOR, 3.293, 95% CI: 2.086–5.200; p <0.001; Table
3A), similar to the risks for moderate and severe AAR (aOR: 3.812,
95%CI: 2.075–7.003, p <0.001, Supplementary Table S6)
in the overall cohort. In HE allergy, multiple food allergens were
significant risk factors, and low-dose reactivity was significant (aOR:
0.312 and 2.248, 95% CI: 0.146–0.668 and 1.085–4.659, p =
0.003 and 0.029, respectively; Table 3B). For CM allergy, a high sIgE
level in milk and low-dose reactivity were significant factors,
respectively (aOR: 2.113 and 3.707, 95% CI: 1.163–3.842 and
1.665–8.257, p = 0.014 and <0.010, respectively; Table
3B).