Variables
Overall cohort (n = 12780) Training cohort (n =8948) Validation cohort (n = 3832)
p value
Sex, n (%) 0.976
Male 7508(58.7) 5256(58.7) 2252(58.8)
Female 5272(41.3) 3692(41.3) 1580(41.2)
Age, Median (IQR) 74.0(69.0, 80.0) 74.0(69.0, 80.0) 74.0(69.0, 80.0) 0.907
Race, n (%) 0.429
White 10613(83.0) 7413(82.8) 3200(83.5)
Black 856( 6.7) 616(6.9) 240(6.3)
Other 1311(10.3) 919(10.3) 392(10.2)
Year of diagnos, n (%) 0.592
2010-2011 4376(34.2) 3089(34.5) 1287(33.6)
2012-2013 4433(34.7) 3089(34.5) 1344(35.1)
2014-2015 3971(31.1) 2770(31) 1201(31.3)
Marital status, n (%) 0.446
Single 1219( 9.5) 834(9.3) 385(10)
Married 7095(55.5) 4988(55.7) 2107(55)
Divorced 1154( 9.0) 795(8.9) 359(9.4)
Other 3312(25.9) 2331(26.1) 981(25.6)
Grade, n (%) 0.719
1061( 8.3) 741(8.3) 320(8.4)
9963(78.0) 6984(78.1) 2979(77.7)
1591(12.4) 1102(12.3) 489(12.8)
165( 1.3) 121(1.4) 44(1.1)
CEA, n (%) 0.448
Positive 4917(38.5) 3451(38.6) 1466(38.3)
Negative 7765(60.8) 5434(60.7) 2331(60.8)
Borderline 98( 0.8) 63(0.7) 35(0.9)
Tumor.size, n (%) 0.918
<3 3550(27.8) 2476(27.7) 1074(28)
3-5 4648(36.4) 3271(36.6) 1377(35.9)
5-7 2896(22.7) 2020(22.6) 876(22.9)
≥7 1686(13.2) 1181(13.2) 505(13.2)
T stage, n (%) 0.734
T1 1832(14.3) 1265(14.1) 567(14.8)
T2 2850(22.3) 2012(22.5) 838(21.9)
T3 7107(55.6) 4976(55.6) 2131(55.6)
T4 991( 7.8) 695(7.8) 296(7.7)
N stage, n (%) 0.684
N0 7988(62.5) 5582(62.4) 2406(62.8)
N1 3587(28.1) 2530(28.3) 1057(27.6)
N2 1205( 9.4) 836(9.3) 369(9.6)
TNM Stage, n (%) 0.851
3866(30.3) 2694(30.1) 1172(30.6)
4122(32.3) 2888(32.3) 1234(32.2)
4792(37.5) 3366(37.6) 1426(37.2)
Months.from.diagnosis.to.treatment,Mean ± SD 1.2 ± 1.2 1.2 ± 1.2 1.1 ± 1.1 0.129
Surgery, n (%) 0.667
No 1242( 9.7) 863(9.6) 379(9.9)
Yes 11538(90.3) 8085(90.4) 3453(90.1)
Radiation, n (%) 0.491
No 5444(42.6) 3794(42.4) 1650(43.1)
Yes 7336(57.4) 5154(57.6) 2182(56.9)
Chemotherapy, n (%) 0.771
No 5288(41.4) 3695(41.3) 1593(41.6)
Yes 7492(58.6) 5253(58.7) 2239(58.4)