Univariate analysis Univariate analysis Univariate analysis Univariate analysis Univariate analysis Multivariate analysis Multivariate analysis Multivariate analysis Multivariate analysis Multivariate analysis
CSS CSS OS OS CSS CSS OS OS
Characteristics HR(95% CI) P value HR(95% CI) P value HR(95% CI) P value HR(95% CI) P value
Sex 0.036 0.148
Male Reference Reference Reference Reference
Female 0.86(0.75-0.99) 0.036 0.9(0.77-1.04) 0.148 0.86(0.75-0.99) 0.036 0.9(0.77-1.04) 0.148
Race 0.762 0.022
White Reference Reference Reference Reference
Black 1.24(0.98-1.58) 0.077 1.07(0.78-1.45) 0.68 1.24(0.98-1.58) 0.077 1.07(0.78-1.45) 0.68
Other 0.97(0.78-1.21) 0.801 1.29(1.04-1.59) 0.02 0.97(0.78-1.21) 0.801 1.29(1.04-1.59) 0.02
Marital status 0.054 0.431
Single Reference Reference Reference Reference
Married 0.71(0.57-0.89) 0.003 1.04(0.8-1.37) 0.765 0.71(0.57-0.89) 0.003 1.04(0.8-1.37) 0.765
Divorced 0.87(0.64-1.18) 0.365 1.09(0.75-1.58) 0.65 0.87(0.64-1.18) 0.365 1.09(0.75-1.58) 0.65
Other 0.94(0.74-1.19) 0.586 0.94(0.69-1.27) 0.688 0.94(0.74-1.19) 0.586 0.94(0.69-1.27) 0.688
Grade <0.001 <0.001
I Reference Reference Reference Reference
II 1.05(0.79-1.4) 0.743 0.77(0.59-1.01) 0.055 1.05(0.79-1.4) 0.743 0.77(0.59-1.01) 0.055
III 1.61(1.17-2.2) 0.003 0.54(0.38-0.76) < 0.001 1.61(1.17-2.2) 0.003 0.54(0.38-0.76) <0.001
IV 2.31(1.44-3.71) < 0.001 0.42(0.15-1.15) 0.091 2.31(1.44-3.71) 0.001 0.42(0.15-1.15) 0.091
T stage <0.001 0.889
T1 Reference Reference Reference Reference
T2 1.32(0.95-1.83) 0.096 0.76(0.59-0.98) 0.034 1.32(0.95-1.83) 0.096 0.76(0.59-0.98) 0.034
T3 2.24(1.67-2.99) < 0.001 0.8(0.64-1.01) 0.058 2.24(1.67-2.99) <0.001 0.8(0.64-1.01) 0.058
T4 4.59(3.3-6.38) < 0.001 1.17(0.82-1.67) 0.382 4.59(3.3-6.38) <0.001 1.17(0.82-1.67) 0.382
N stage 0.181
N0 Reference Reference Reference Reference
N1 1.49(1.28-1.74) < 0.001 0.97(0.82-1.14) 0.688 1.49(1.28-1.74) < 0.001 0.97(0.82-1.14) 0.688
N2 2.55(2.14-3.04) < 0.001 0.83(0.65-1.07) 0.145 2.55(2.14-3.04) < 0.001 0.83(0.65-1.07) 0.145
TNM Stage <0.001 0.465
Reference Reference Reference Reference
1.81(1.43-2.29) <0.001 1.03(0.84-1.25) 0.797 1.81(1.43-2.29) <0.001 1.03(0.84-1.25) 0.797
2.65(2.13-3.31) <0.001 0.94(0.78-1.14) 0.543 2.65(2.13-3.31) <0.001 0.94(0.78-1.14) 0.543
CEA < 0.001 0.231
Positive Reference Reference Reference Reference
Negative 0.63(0.55-0.72) < 0.001 1.09(0.93-1.28) 0.289 0.63(0.55-0.72) <0.001 1.09(0.93-1.28) 0.289
Borderline 2.04(1.01-4.11) 0.046 1.97(0.63-6.16) 0.244 2.04(1.01-4.11) 0.046 1.97(0.63-6.16) 0.244
Tumor size < 0.001 0.019
<3 Reference Reference Reference Reference
3-5 1.28(1.07-1.54) 0.007 0.89(0.74-1.06) 0.189 1.28(1.07-1.54) 0.007 0.89(0.74-1.06) 0.189
5-7 1.48(1.21-1.81) < 0.001 0.8(0.65-0.99) 0.039 1.48(1.21-1.81) < 0.001 0.8(0.65-0.99) 0.039
≥7 1.96(1.54-2.48) < 0.001 0.76(0.56-1.03) 0.078 1.96(1.54-2.48) < 0.001 0.76(0.56-1.03) 0.078
Months.from.diagnosis.to.treatment 1.02(0.96-1.07) 0.542 1.19(1.14-1.24) < 0.001 1.02(0.96-1.07) 0.542 1.19(1.14-1.24) <0.001
Cherapy 0.073 0.059
Surgery Reference Reference Reference Reference
Combined 0.88(0.77-1.01) 0.073 1.15(0.99-1.34) 0.059 0.88(0.77-1.01) 0.073 1.15(0.99-1.34) 0.059