AUTHOR CONTRIBUTIONS
Thabo Hamiwe and Marthie M. Ehlers: jointly involved in the conceptualisation of study. Thabo Hamiwe: experimental procedures, results analysis and writing and editing of the original manuscript. Debbie White and Susan Klugman: recruitment of study participants, review and interpretation of clinical records and review and editing of original manuscript. Anthony Smith and Arshad Ismail: funding and facilitation of whole genome sequencing and review and editing of original manuscript. Stanford Kwenda:bioinformatics analysis and review and editing of original manuscript.Lore Van Bruwaene: interpretation of clinical findings and review and editing of original manuscript. Ameena Goga and Marleen M. Kock: analysis of study findings and review and editing of original manuscript. Marthie M. Ehlers: Funding of the study, study supervision, review of study findings and review and editing of original manuscript.