Uni-variate and multivariate analysis of 30-day mortality among three groups
We analyzed and compared clinical data of BSIs in all patients with ALL. uni-variate and multi-variate analyses of 30-day mortality among the three groups are shown in Fig.4. Variables with p < 0.1 in uni-variate analysis were included in the multi-variable analysis. The results revealed that acute respiratory failure was an independent risk factor in all three groups (AYAs: OR 21.554, adult: OR 22.930; children, OR 23.934; P < 0.05). However, AYAs also present clinical features other than those of children and adults.
In our study, BSI-related mortality within 30 days in AYAs was closely related to hospital length>14 days (OR, 0.069; P<0.05) and renal inadequacy (creatinine≥177μmoI/L) (OR, 15.054; P<0.05). The independent risk factors for adult ALL patients were more complex. Patient characteristics that contributed to worse mortality outcomes in adult ALL patients were relapsed or uncontrolled disease status, Charlson Comorbidity Index>3, 72-h IIAT, and APTT> 40. Notably, the risk factors for BSI-related mortality in children were relatively simple and closely related to the use of vasopressors (OR 2.955; P < 0.05). Most other variables (sex and profound neutropenia) showed no significant differences.