Changes in immunological parameters
Comparing sIgE levels to storage proteins (Ana o3/Ara h2) from before OIT (t0) to after up-dosing completion (t1), the CN group showed a decreasing trend in mean sIgE levels (Fig. 5A). In contrast, the peanut group (n=27) exhibited varied sIgE level trajectories, resulting in similar means at both measurement points (t0 and t1).
In the analysis of 21 patients with available data who underwent a second OFC, the CN group continued its decreasing trend until the end (t3). Similarly, in the peanut group, after an initial increase, we observed a decrease in most patients before completing the second OFC (Figure 5B). No significant differences were observed when comparing patients who tolerated the final challenge to those who did not.