Effects of different doses
Regarding dose effects, nine studies investigated the effects of corticosteroids at various doses. MPS/MPA and BTM had better results in healthy joint tissues when lower doses were employed, while results for DEX and TA were not unanimous (Murphy et al., 2000; Fubini et al., 2001; Frean, Cambridge & Lees, 2002; Doyle et al., 2005). DEX showed no dose effects in three studies and TA in one (Tung, Venta & Caron, 2002; Tung et al., 2002; Busschers, Holt & Richardson, 2010). One group showed better results for decreasing proteolytic enzymes with higher doses and better results for ECM components with lower doses for both corticosteroids (Richardson & Dodge, 2003).