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Figure 1 . Flow diagram of the selection process of included studies for both questions of this review.
Figure 2. Risk of bias of included studies. A) Assessment through the Cochrane risk of bias tool for RCTs and pre-clinical in vivo studies with horses; 1 = Random sequence generation (selection bias); 2 = Allocation concealment (selection bias); 3 = Blinding of participants and researchers (performance bias); 4 = Blinding of outcome assessors (detection bias); 5 = Incomplete outcome data (attrition bias); 6 = Selective reporting (reporting bias); 7 = Other bias; FINAL = Final criteria of study; B) Assessment through the MINORs tool for observational studies.
Figure 3. Risk of bias of included studies for question 2. Assessment through the Cochrane risk of bias tool for pre-clinicalin vivo studies with horses; 1 = Random sequence generation (selection bias); 2 = Allocation concealment (selection bias); 3 = Blinding of participants and researchers (performance bias); 4 = Blinding of outcome assessors (detection bias); 5 = Incomplete outcome data (attrition bias); 6 = Selective reporting (reporting bias); 7 = Other bias; FINAL = Final criteria of study.
Table 1. Search strategy employed in each database.