Effects of different doses
Regarding dose effects, nine studies investigated the effects of
corticosteroids at various doses. MPS/MPA and BTM had better results in
healthy joint tissues when lower doses were employed, while results for
DEX and TA were not unanimous (Murphy et al., 2000; Fubini et al., 2001;
Frean, Cambridge & Lees, 2002; Doyle et al., 2005). DEX showed no dose
effects in three studies and TA in one (Tung, Venta & Caron, 2002; Tung
et al., 2002; Busschers, Holt & Richardson, 2010). One group showed
better results for decreasing proteolytic enzymes with higher doses and
better results for ECM components with lower doses for both
corticosteroids (Richardson & Dodge, 2003).