Methods
All experiments with human samples were conducted according to approval
of the local ethics committee of Rhineland Palatinate (authorization no.
837.303.13 and 837.054.17 (10888)) and written informed consent was
obtained from all participants. Murine experiments were in accordance
with current federal, state, and institutional guidelines (authorisation
no. 23 177-07/G 18-1-015).
Methods are described in brief, for further details see Supplementary
Methods.