|
|
TB model group vs. Normal group |
DNA IM group vs. TB model group |
DNA IM group vs. TB model group |
DNA IM group vs. TB model group |
DNA
IM group vs. TB model group |
DNA EP group vs. TB model group |
DNA EP
group vs. TB model group |
DNA EP group vs. TB model group |
DNA EP
group vs. TB model group |
|
|
|
|
10μg |
50μg |
100μg |
200μg |
10μg |
50μg |
100μg |
200μg |
|
NM_010491 |
Iapp |
832↑ |
NO |
NO |
620↓ |
981↓ |
665↓ |
640↓ |
760↓ |
843↓ |
Islet amyloid polypeptide, has direct toxicity to islet B cells,
mediates local inflammatory reaction, leading to pancreatic islet
dysfunction (48, 49, 81) , an important pathological factor causing
T2DM. |
NM_009129 |
Scg2 |
428↑ |
NO |
NO |
391↓ |
363↓ |
382↓ |
345↓ |
396↓ |
399↓ |
Secretogranin II, has anti-inflammatory properties and
participates in inflammatory reaction, involves in the pathogenesis of
diabetes(55, 56). |
NM_001042711 |
Amy2a5 |
365↑ |
NO |
NO |
239↓ |
356↓ |
285↓ |
272↓ |
457↓ |
400↓ |
Amylase alpha 2A, a member of the amylase family, involves
in starch digestion and glycogen metabolism(61). |
NM_001003405 |
Try5 |
337↑ |
NO |
NO |
314↓ |
295↓ |
330↓ |
287↓ |
313↓ |
239↓ |
Trypsin 5, involves in the hydrolysis of proteins and peptide
chains. |
NM_007693 |
Chga |
326↑ |
NO |
NO |
433↓ |
440↓ |
317↓ |
342↓ |
440↓ |
408↓ |
Chromogranin A, has anti-inflammatory properties and participates
in inflammatory reaction, involves in the pathogenesis of diabetes (56,
82). |
NM_025350 |
Cpa1 |
309↑ |
NO |
NO |
312↓ |
297↓ |
274↓ |
305↓ |
307↓ |
307↓ |
Carboxypeptidase A1, hydrolyzes C-terminal aromatic or neutral
aliphatic amino acids residues of in proteins and polypeptide
substrates. |
NM_008100 |
Gcg |
260↑ |
NO |
NO |
326↓ |
324↓ |
323↓ |
212↓ |
341↓ |
275↓ |
Glucagon, a kind of pleiotropic hormone with metabolic effects
secreted by islet α cells, which can promote glycogen decomposition and
gluconeogenesis to increase blood sugar, and also can promote fat
decomposition and lipid oxidation(83). |
NM_001126318 |
Gm13011 |
218↑ |
NO |
NO |
218↓ |
234↓ |
228↓ |
178↓ |
219↓ |
231↓ |
Elastase 3A, a member of the elastase family, involves in
the hydrolysis of various proteins. |
NM_198627 |
Vstm2l |
198↑ |
NO |
NO |
199↓ |
136↓ |
180↓ |
182↓ |
197↓ |
197↓ |
V-set and transmembrane
domain containing 2 like, a novel modulator of neuroprotective activity.
Overexpression of VSTM2L in a variety of cancer samples regulates IL-4
signaling pathway, mainly enrichs in cell signal transduction, immune
response, inflammatory response, calcium binding,
etc(84). |
NM_008386 |
Ins1 |
177↑ |
NO |
NO |
181↓ |
259↓ |
207↓ |
184↓ |
253↓ |
182↓ |
Insulin 1, a protein hormone secreted by the islets β cells,
which can reduce blood sugar and promote the synthesis of glycogen, fat
and protein. |
NM_153518 |
Ccdc65 |
163↑ |
NO |
NO |
87↓ |
137↓ |
168↓ |
154↓ |
115↓ |
159↓ |
Coiled-coil domain containing 65, a member of the coiled-coil
domain-containing protein family, encodes many proteins like motor and
skeletal proteins and involved in protein refolding and molecular
recognition systems(85). |
NM_011646 |
Try4 |
140↑ |
NO |
NO |
250↓ |
253↓ |
252↓ |
240↓ |
205↓ |
248↓ |
Trypsin 4, involved in the hydrolysis of proteins and peptide
chains. |
NM_009430 |
Prss2 |
135↑ |
NO |
NO |
179↓ |
206↓ |
151↓ |
198↓ |
205↓ |
137↓ |
Serine protease 2, a member of the trypsin family, plays a role
in food digestion. |
NM_029706 |
Cpb1 |
121↑ |
NO |
NO |
125↓ |
103↓ |
124↓ |
124↓ |
124↓ |
124↓ |
Carboxypeptidase B1, cleaves the C-terminal of lysine or
arginine, used as a serological marker of acute
pancreatitis. |
NM_026925 |
Pnlip |
112↑ |
NO |
NO |
60↓ |
71↓ |
219↓ |
111↓ |
187↓ |
145↓ |
Pancreatic lipase, a member of the lipase family, secreted by the
pancreas, hydrolyzes dietary triglycerides in the small
intestine(86). |
NM_007919 |
Cela2a |
99↑ |
NO |
NO |
103↓ |
103↓ |
103↓ |
84↓ |
102↓ |
81↓ |
Chymotrypsin-like elastase 2A, a member of the elastase family,
circulates in plasma, reduces platelet hyperactivation, triggers insulin
secretion and degradation, and increases insulin
sensitivity(87). |
.NM_007694 |
Chgb |
91↑ |
NO |
NO |
91↓ |
89↓ |
66↓ |
49↓ |
54↓ |
64↓ |
Chromogranin B, a member of the chromogranins/secretogranins protein
family, has both extra-cellular and intra-cellular roles in the
neuroendocrine system. |
NM_009049 |
Resp18 |
81↑ |
NO |
NO |
80↓ |
81↓ |
76↓ |
63↓ |
43↓ |
59↓ |
Regulated endocrine specific protein 18, a novel secreted peptide,
specifically expressed in mammalian central nervous system and endocrine
system (88). |
NM_172816 |
Slc30a8 |
78↑ |
NO |
NO |
58↓ |
44↓ |
72↓ |
80↓ |
69↓ |
60↓ |
Solute carrier family 30 member 8, a zinc transporter, transports Zinc
from cytoplasm to insulin secretory granules in the pancreatic
beta-cells(51). |
NM_007446 |
Amy1 |
75↑ |
NO |
NO |
53↓ |
57↓ |
62↓ |
65↓ |
54↓ |
58↓ |
Amylase 1, hydrolyzes 1,4-alpha glycosidic bonds within starch, and
plays a key role in starch digestion. |