1.3.4 MiRNA negatively regulates lncRNA
TMPO antisense RNA 1 (TMPO-AS1) gene, located on chromosome 12, served
as the diagnostic and prognostic marker of lung adenocarcinoma (LUAD).
MiR-383-5p binding with lnc TMPO-AS1 and inhibits its expression,
significantly reducing tumorigenesis and progression of LUAD[26].
MALAT1 is each individually suppressed by MiR-216a,miR-216b and
miR-217. Especially, miR-216a and MALAT1’s association further induced
G2/M arrest and cell cycle inhibition, decreased cell viability and
apoptosis in pancreatic cancer cells[27].