Intervention and measurement
The routin regimen include: Azithromycin 500 mg/daily,
Hydroycholoroquine 200 mg/12 h (subgroup A), which can fallowed with
Lopinavir/ritonavir ( 200/50 mg tablets two times/12h) if patients need
and their hospitalization continued and their conditions worsened, with
or with out Ribavirin (1200 mg/daily) (subgroup B).
Patients received Acetaminophen for fever as needed,
Antiacid(Pantoprazole) for prevention of gastritis induced by stress or
drugs, and other antimicrobial empiric treatments for secondary
bacterial pneumonia if they need (Levofloxacin 500 mg/daily, vancomycin
1gr/12h, meropenem 1gr/8h, ceftriaxone 1gr/12h).
The severity of patient’s disease evaluated with National Early Warning
Score (NEWS) which is used for standardizing the assessment of acute
illness severity in the NHS (physicians, 2017), in this scoring we gave
scores to patients vital signs (PR,RR,T,SO2,SYS BP), the level of
consciousness and requirement to supplemental oxygen at the first visit
when they admitted, scores between 1-4 show Mild disease, 5-6 show
Moderate disease and >=7 show severe disease, and the
degree of involvement of their lungs at chest CT scans to compare the
severity of disease between our two groups with an expert radiologist in
this hospital, according to this score both lungs divided into 5 lobes
and each lobe can get a score of involvement between 1 to 5 so every CT
scans scored between 1 to 25 (Assistant, 2020).