Therapeutic effects of oseltamivir
However, severity of disease in patients in the oselta group were more
than the control group (5.02 vs 4.2, p=0.01), time to recovery and
length of stay in hospital were significantly shorter in patients in
oselta group (4.9 vs 6.6 days, P<0.001).
Similarly, the mortality rate was lower in oselta group (1.7% vs 6.7%,
p=0.06) and after adjusting the disease severity by multivariate
regression analysis between two groups had a statistically significant
difference (OR=5.29, 95% cl=1.11,25.02, p=0.03).
By univariate and multivariate regression analysis, the comparison of
the incidence of ICU admission (6.7%, vs 11.5%, p=0.1), and the
incidence of mechanical ventilation (2.5% vs 4.8%, p=0.3), showed
lower percentage in oselta group but did not differ statistically
significant.
A comparison of length of hospital stays between two subgroup A
together, and two subgroup B together, showed the similar results, were
shorter in oselta group, but the other outcomes did not have a
particular result and cannot be evaluated due to the small sample size
between subgroups A (table 3,4). Our results of multivariate regression
analysis showed that by comparing subgroup A1 with subgroup A2, length
of hospital stay was shorter (AOR=2.2, 95%Cl=1.48-2.92,
P<0.001) than comparing group 1 and group2 (AOR=1.89,95%
Cl=1.03,2.75, P<0.001), or subgroup B1 with subgroup
B2(AOR=1.5,95% Cl=0.18-2.83, P=0.02). Therefore, maybe it can show
that, the efficacy of oseltamivir therapy in mild conditions have a
better response in duration of recovery and length of hospital stay.