Statistical analysis
The statistical analysis was performed using statistical package STATA version 14. A p value of 0.05 or less (<=0.05) was considered statistically significant. The power of study was 80% and alfa was 0.05.
Descriptive statistic was reported as mean, standard deviation, percentage and frequency. Confidence interval was 0.95 (Cl, 0.95).
Independent samples T test and chi-square test was used to compare the differences between Baseline characteristics of two groups.
Linear regression analysis was used to investigate the relationship between continues outcomes and treatment. Besides, a logistic regression was used to investigate the relationship between binary dependent variables and treatment. Adjustment for severity was performed by multiple linear and multiple logistic regression.