3.2 CUR ameliorate the morphology changes of psoriasis-like dermatitis in mice
We further processed the skin tissues collected from all groups of mice for HE staining and IFC staining. The results showed that oral curcumin alleviated IMQ-induced dermatitis in mice, such as parakeratosis, erythema, and infiltrating inflammatory cells (Figure. 2A). Moreover, PCNA was a highly proliferative marker of keratinocytes at psoriatic lesions [11]. The IFC results showed that CUR significantly decreased the expression of PCNA in the back skin of model mice (Figure. 2B). Thus, the data revealed that CUR can markedly inhibit over-proliferating keratinocytes in IMQ-induced lesions of mice.