3.2 CUR ameliorate the morphology changes of psoriasis-like
dermatitis in mice
We further processed the skin tissues collected from all groups of mice
for HE staining and IFC staining. The results showed that oral curcumin
alleviated IMQ-induced dermatitis in mice, such as parakeratosis,
erythema, and infiltrating inflammatory cells (Figure. 2A). Moreover,
PCNA was a highly proliferative marker of keratinocytes at psoriatic
lesions [11]. The IFC results showed that CUR significantly
decreased the expression of PCNA in the back skin of model mice (Figure.
2B). Thus, the data revealed that CUR can markedly inhibit
over-proliferating keratinocytes in IMQ-induced lesions of mice.