3.1 Curcumin inhibits psoriasis-like skin lesions induced by IMQ
To further clarify the regulatory effect of CUR on psoriasis, we constructed psoriasis-like skin lesions induced by IMQ (Figure. 1A). As shown in Figure.1B-D, PASI scores were largely increased in IMQ-induced mice than in control mice. CUR could significantly decrease PASI scores and epidermal thickness in affected lesions of IMQ-induced mice (Figure. 1B-E). Therefore, CUR could relieve the IMQ-induced mouse skin lesions and reduce the PASI scores in the affected areas.