##Reduced overload of iron by ferroptosis inhibition
Iron overload plays an important role
in oxidative stress, and the accumulation and lipid peroxidation of
Fe2+ are the key factors of ferroptosis. To explore
SRS 16-86 on overload of iron on DN, an iron ion detection kit was used
to measure the iron content. In this study, the overload of iron in the
DM group was significantly increased compared with that in the control
group, while SRS 16-86 treatment could reduce the content of iron
compared with the DN group, indicating a reduced overload of iron
(Figure 3A).