Figure
5. Reduction of DN inflammation by ferroptosis inhibitor. Expression of
tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and
intercellular adhesion molecule 1 (ICAM-1) in the kidneys of rats in the
DN group significantly increased in comparison to the control group.
Treatment with the SRS 16-86 attenuated the levels of expression
(n=6/group). (ns:P>0.05; *P<0.05;
**P<0.01; ***P<0.001; ****P<0.0001)
Figure 6. Improvement of organizational structure after DN via the
inhibition of ferroptosis. Obvious disorder was visible on the
transverse section of the kidney with the HE staining after DN while SRS
16-86 treatment significantly reduced destruction of the organizational
structure (n=6/group).