Figure 3 Reduced overload of iron and reactive oxygen species (ROS) expression via the inhibition of ferroptosis. The overload of iron and ROS expression in the DM group were significantly increased compared with the control group, while SRS 16-86 treatment could reduce the content of iron compared with the DN group (n=6/group). (ns:P>0.05; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001)