Figure 5. Reduction of DN inflammation by ferroptosis inhibitor. Expression of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and intercellular adhesion molecule 1 (ICAM-1) in the kidneys of rats in the DN group significantly increased in comparison to the control group. Treatment with the SRS 16-86 attenuated the levels of expression (n=6/group). (ns:P>0.05; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001)
Figure 6. Improvement of organizational structure after DN via the inhibition of ferroptosis. Obvious disorder was visible on the transverse section of the kidney with the HE staining after DN while SRS 16-86 treatment significantly reduced destruction of the organizational structure (n=6/group).