##Animals
The 6 weeks-age of male Sprague-Dawley rats weighing 160–180 g were purchased from the Laboratory Animal Center of the Academy of Military Medical Sciences (Beijing, China). The animals were placed in a humidity- and temperature-controlled environment, with a light cycle of 12 h, with 3 animals in each cage, and free access to food and water. Experiments were performed under a project license (No. IRM-DWLL-2020019) granted by Ethics Committee of the Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, in compliance with institutional guidelines for the care and use of animals. A protocol was prepared and passed our team’s proposal report before the study, while with no registration as it’s not a clinical trial.