References
1. Mitchell JP, Carmody RJ: NF-κB and the Transcriptional Control of Inflammation . Int Rev Cell Mol Biol 2018,335 :41-84.
2. Gilmore TD: Introduction to NF-kappaB: players, pathways, perspectives . Oncogene 2006, 25 (51):6680-6684.
3. Commission CP: Pharmacopoeia of the People’s Republic of China 2020 Edition . Beijing: China Pharmaceutical Science and Technology Press; 2020.
4. Li H, Wu KX, Shi KH, Tang L, Liang CY: Research progress on chemical constituents, pharmacological activities and clinical application of Bolbostemma paniculatum . China Journal of Chinese Materia Medica 2021, 46 (17):4314-4322.
5. Yu L, Yu T, Ma R: Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum . Carcinogenesis 1995,16 (12):3045-3048.
6. Yu TX, Ma RD, Yu LJ: Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor, and antitumor-promoting effects . Acta Pharmacol Sin 2001, 22 (5):463-468.
7. Inamdar S, Tylek T, Thumsi A, Suresh AP, Jaggarapu M, Halim M, Mantri S, Esrafili A, Ng ND, Schmitzer E et al : Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models . Biomaterials 2023, 293 :121973.
8. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH et al :Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis . Nature 2018,556 (7702):501-504.
9. Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF et al :Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages . Cell Metab 2022,34 (3):487-501.e488.
10. Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M et al : Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses . Nat Cell Biol2022, 24 (3):353-363.
11. Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E et al :Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 . Nature 2018,556 (7699):113-117.
12. Fioranelli M, Bottaccioli AG, Bottaccioli F, Bianchi M, Rovesti M, Roccia MG: Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based . Front Immunol 2018,9 :2031.
13. Amirshahrokhi K: Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice . Int Immunopharmacol 2019, 76 :105884.
14. Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B et al : Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization . Immunity 2015, 42 (3):419-430.
15. De Souza DP, Achuthan A, Lee MK, Binger KJ, Lee MC, Davidson S, Tull DL, McConville MJ, Cook AD, Murphy AJ et al : Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages . J Clin Invest 2019,129 (10):4239-4244.
16. Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice CM, Rouault TA, Cassel T, Higashi RM et al :Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase . Nat Commun2020, 11 (1):698.
17. Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T et al : Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation .Cell Metab 2016, 24 (1):158-166.
18. Li C, Wang Y, Li Y, Yu Q, Jin X, Wang X, Jia A, Hu Y, Han L, Wang Jet al : HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection . Sci Rep 2018, 8 (1):3603.
19. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH et al :Succinate is an inflammatory signal that induces IL-1β through HIF-1α . Nature 2013, 496 (7444):238-242.
20. Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DGet al : Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages . Cell Metab 2015,21 (1):65-80.
21. Rosenberg G, Riquelme S, Prince A, Avraham R:Immunometabolic crosstalk during bacterial infection . Nat Microbiol 2022, 7 (4):497-507.
22. Qin W, Qin K, Zhang Y, Jia W, Chen Y, Cheng B, Peng L, Chen N, Liu Y, Zhou W et al : S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate . Nat Chem Biol2019, 15 (10):983-991.
23. Liu M, Zhang P, Lyu X: [Research progress of metabolism reprogramming in regulating macrophage polarization] . Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020, 32 (6):765-768.
24. Balic JJ, Albargy H, Luu K, Kirby FJ, Jayasekara WSN, Mansell F, Garama DJ, De Nardo D, Baschuk N, Louis C et al : STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression . Nat Commun 2020, 11 (1):3816.
25. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K et al :Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels . J Biol Chem 2016, 291 (27):14274-14284.
26. Sun KA, Li Y, Meliton AY, Woods PS, Kimmig LM, Cetin-Atalay R, Hamanaka RB, Mutlu GM: Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response .Elife 2020, 9 .
27. Gautam P, Maenner S, Cailotto F, Reboul P, Labialle S, Jouzeau JY, Bourgaud F, Moulin D: Emerging role of IκBζ in inflammation: Emphasis on psoriasis . Clin Transl Med 2022,12 (10):e1032.
28. Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T: The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA . J Mol Biol 2008,379 (1):122-135.
29. Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N et al :Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism . Nat Metab 2022, 4 (5):534-546.