Screening of miRNAs related to liver injury
E. multiloculari s enters the liver tissue along with the blood
circulation, which induces an immune response in the liver and recruits
a large number of inflammatory cells that release pro-inflammatory
cytokines, and promotes the proliferation of fibroblasts. With the
expansion of the lesion, immune tolerance appears in the liver, the
expression of anti-inflammatory cytokines increases, the imbalance
between fibrosis formation and degradation aggravates the degree of
liver fibrosis, and the expression of collagen increases. Therefore, We
screened 4 miRNAs related to liver injury(inflammatory response, immune
response, fibrosis process)(Table 4).
mmu-miR-30e-3p may target IL-1rn mRNA to participate in inflammatory
response. mmu-miR-125b-5p may target was mRNA to regulate the immune
response. mmu-miR-30c-2-3p may target prr5l gene to regulate the
fibroblast migration. And mmu-miR-203-3p may target ctss mRNA to
regulate the immune response.
Table 4 Liver injury-related miRNA
expression