Screening of miRNAs related to liver injury
E. multiloculari s enters the liver tissue along with the blood circulation, which induces an immune response in the liver and recruits a large number of inflammatory cells that release pro-inflammatory cytokines, and promotes the proliferation of fibroblasts. With the expansion of the lesion, immune tolerance appears in the liver, the expression of anti-inflammatory cytokines increases, the imbalance between fibrosis formation and degradation aggravates the degree of liver fibrosis, and the expression of collagen increases. Therefore, We screened 4 miRNAs related to liver injury(inflammatory response, immune response, fibrosis process)(Table 4). mmu-miR-30e-3p may target IL-1rn mRNA to participate in inflammatory response. mmu-miR-125b-5p may target was mRNA to regulate the immune response. mmu-miR-30c-2-3p may target prr5l gene to regulate the fibroblast migration. And mmu-miR-203-3p may target ctss mRNA to regulate the immune response.
Table 4 Liver injury-related miRNA expression