Figure1
Signaling pathways involved in YAP/TAZ
Figure1:Mst1/2 kinases and SAV1 form a complex that phosphorylates and
activates LATS1/2 [48]. LATS1/2 kinases in turn phosphorylate and
inhibit the transcriptional coactivator YAP/TAZ. YAP/TAZ phosphorylation
prevents its nuclear localization and leads to cytoplasmic sequestration
by binding to the 14-3-3 adaptor protein. Furthermore, YAP/TAZ can be
targeted for degradation through subsequent phosphorylation of casein
kinase 1. Inactivation or loss of MST1/2 and LATS1/2 can lead to
dephosphorylation and nuclear translocation of YAP/TAZ. YAP/TAZ block
β-catenin-NICD-mediated expression of the Notch ligand Dll4. In the
presence of Wnt ligands, YAP/TAZ is released from the complex, and
β-catenin enters the nucleus, thus activating the pathway .