Abstract
YAP/TAZ are two homologous
transcriptional coactivators that promote cell proliferation, stem cell
maintenance, and tissue homeostasis. Activated YAP/TAZ reflects the
”social” behavior of cells, including cell adhesion and mechanical
signals that cells receive from tissue structures and the surrounding
extracellular matrix (ECM). Simultaneous activation or overexpression of
YAP/TAZ has been shown to lead to cellular transformation and tumor
development. Intestinal diseases are mostly inflammatory and
tumor-based, and YAP/TAZ plays an important role in this process.
However, many roles of the YAP/TAZ in the course of intestinal disease
are not clear. Therefore, this paper discusses the YAP/TAZ-binding
proteins, involved pathways, and related pathological processes in the
development of inflammatory bowel disease and intestinal cancer disease.
Keywords: YAP/TAZ, TEAD, Smad2/3, Hippo, Notch, Wnt,
inflammatory bowel disease, intestinal cancer
Running title: Overview of YAP/TAZ in intestinal diseases