Binding transcription factor dependent interaction Downstream molecule References
RUNX RUNX2 cooperates with YAP/TAZ to promote the transformation of epithelial cells into mesenchymal cells.RUNX3 acts as a tumor suppressor by inhibiting the YAP/TAZ-TEAD complex and disrupting the transcription of its downstream genes. p53 and / or p73 [27-32]
KLF4 The coexpression of YAP/TAZ and KLF4 promote differentiation, while knockdown of KLF4 inhibits YAP/TAZ-induced differentiation. BCL2L1 and BIRC5 [33,34]
TBX5 YAP/TAZ can stimulate TBX5 transcription by interacting with multiple domains. [30,35]
NKX2-1 YAP/TAZ and extended TEAD direct NKX2-1 to its AT1-specific site and prevent it from binding to AT2-specific sites. [2,36]
Bmp4 Bmp4 is a target of endothelial YAP/TAZ during osteogenesis . Cyclic activation of YAP/TAZ transcriptional activity occurs in endothelial cells, and transactivated YAP/TAZ promotes Bmp4 expression to promote their ossification. Grem1 [37,38]
Ncoa6 The Ncoa6 subunit has been shown to interact with mammalian YAP/TAZ to methylate H3K4 and activate transcription. H3K4 [39]