Binding transcription factor |
dependent interaction |
Downstream molecule |
References |
RUNX |
RUNX2 cooperates with YAP/TAZ to promote the transformation of
epithelial cells into mesenchymal cells.RUNX3 acts as a tumor suppressor
by inhibiting the YAP/TAZ-TEAD complex and disrupting the transcription
of its downstream genes. |
p53 and / or p73 |
[27-32] |
KLF4 |
The coexpression of YAP/TAZ and KLF4 promote differentiation,
while knockdown of KLF4 inhibits YAP/TAZ-induced differentiation. |
BCL2L1 and BIRC5 |
[33,34] |
TBX5 |
YAP/TAZ can stimulate TBX5
transcription by interacting with multiple domains. |
? |
[30,35] |
NKX2-1 |
YAP/TAZ and extended TEAD direct NKX2-1 to its AT1-specific
site and prevent it from binding to AT2-specific sites. |
? |
[2,36] |
Bmp4 |
Bmp4 is a target of endothelial YAP/TAZ during osteogenesis .
Cyclic activation of YAP/TAZ transcriptional activity occurs in
endothelial cells, and transactivated YAP/TAZ promotes Bmp4 expression
to promote their ossification. |
Grem1 |
[37,38] |
Ncoa6 |
The Ncoa6 subunit has been shown to interact with mammalian
YAP/TAZ to methylate H3K4 and
activate transcription. |
H3K4 |
[39] |