Participate in the pathway |
References |
Rho-ROCK1 signaling pathway |
As a nuclear transmission mechanical
signal, YAP/TAZ activity is triggered by ECM stiffness and cell shape,
which is regulated by Rho GTPase activity and actomyosin cytoskeletal
tension. When ROCK1 is activated by RhoA-GTP, various proteins, such as
myosin light chain, are phosphorylated, resulting in a decrease in free
globular actin, actin aggregation, and the appearance of stress fibers
[65,66]. |
TGF-β signaling pathway |
In human
dermal fibroblasts, YAP/TAZ cooperates with the transcription factors
AP-1 and Smad7 to regulate TGF-β signaling. Decreased YAP/TAZ levels
lead to activation of AP-1 activity, which induces Smad7 and inhibits
the TGF-β pathway [15,67,68]. |
PI3K signaling pathway |
The Hippo tumor suppressor pathway restricts
growth factor receptor signaling through the PI3K pathway, and YAP/TAZ
acts as a redundant regulator of the PI3K/AKT pathway
[15,69]. |
GPCR signaling pathway |
Conjugation of GPCRs to Gα12/13, Gαq/11 or
Gαi/o (e.g., LPA, thrombin receptors) activates YAP/TAZ. Conversely,
GPCRs coupling to Gαs (e.g., epinephrine and glucagon receptors) inhibit
YAP/TAZ [15,70]. |
KRAS signaling pathway |
KRAS induces posttranscriptional modification
of YAP/TAZ and enhances its transcriptional activity through the MAPK
pathway [15,71]. |
EGFR signaling pathway |
YAP/TAZ silencing reduces maintenance of
resistance, whereas YAP/TAZ overexpression reduces the responsiveness of
sensitive parental cells to EGFR inhibitors
[72,73]. |