Methods
This was an IRB-approved retrospective medical record review of subjects
diagnosed with SCD. Individuals were initially identified from
International Classification of Diseases, Tenth Revision, Clinical
Modification 10 (ICD10) codes for PED visits in SCD patients from 2014
to 2019. Retrospective chart review was performed using PED and
inpatient medical record documentation. Inclusion criteria were SCD
patients aged 2-12 years who presented to the University of Maryland
Medical Center (UMMC) PED between 2016-2018. Exclusion criteria included
non-SCD patients, patients less than 2 years of age, or greater than 12
years of age, and patients evaluated at hospitals other than UMMC. Each
PED encounter was counted as a separate data point.
We performed bivariate analyses comparing clinical and demographic
variables between subjects who were febrile vs. afebrile on presentation
to the PED, as well as those who were ultimately diagnosed with ACS
compared to those who were not. Analysis of categorical variables was
performed using Chi-square or Fischer exact test as appropriate. We
performed multivariable logistic regression modelling to identify
significant predictors of an ACS diagnosis. Analyses were performed
using SAS 9.4 (Cary, NC).