Methods
This was an IRB-approved retrospective medical record review of subjects diagnosed with SCD. Individuals were initially identified from International Classification of Diseases, Tenth Revision, Clinical Modification 10 (ICD10) codes for PED visits in SCD patients from 2014 to 2019. Retrospective chart review was performed using PED and inpatient medical record documentation. Inclusion criteria were SCD patients aged 2-12 years who presented to the University of Maryland Medical Center (UMMC) PED between 2016-2018. Exclusion criteria included non-SCD patients, patients less than 2 years of age, or greater than 12 years of age, and patients evaluated at hospitals other than UMMC. Each PED encounter was counted as a separate data point.
We performed bivariate analyses comparing clinical and demographic variables between subjects who were febrile vs. afebrile on presentation to the PED, as well as those who were ultimately diagnosed with ACS compared to those who were not. Analysis of categorical variables was performed using Chi-square or Fischer exact test as appropriate. We performed multivariable logistic regression modelling to identify significant predictors of an ACS diagnosis. Analyses were performed using SAS 9.4 (Cary, NC).