*To whom corresponding author should be
addressed at:
Li Li, Nanfang Hospital, Southern Medical University, 1838
North Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.Tel:+86-13318827908,
Email:npfklily@163.com.
Longquan Shao, Nanfang Hospital, Southern Medical University, 1838 North
Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.Tel:+86-15989283921,
Email:shaolongquan@smu.edu.cn.
Word count: 7052
Number of references: 105
Abstract
Internal
and external factors cause various types of wounds on the skin.
Infections, nonhealing chronic wounds, and aesthetic and functional
recovery all cause challenges for clinicians. The development of
nanotechnology in biomedicine has brought many new materials, methods
and therapeutic targets for the treatment of wounds, which are believed
to have great prospects. In this
work, the nanomaterials applied in different stages to promote wound
healing and systematically expounded their mechanisms were reviewed.
Then, the difficulties and defects of the present research and suggested
methods for improvement were pointed out. Moreover, based on the current
application status of nanomaterials in wound treatment, some new ideas
for subsequent studies were proposed and the feasibility of intelligent
healing by real-time monitoring, precision regulation, and signal
transmission between electronic signals and human nerve signals in the
future were discussed. This review will provide valuable directions and
spark new thoughts for researchers.
Key words: nanomaterials, wound healing, mechanism, intelligent healing
challenges