Figure 1. Possiblemechanisms of promoting wound healingby nanomaterials. A) Nanomaterials promote the accumulation of red blood cells, platelets and clotting factors at the damaged vasculature to form blood clots. B) Nanomaterials can kill microorganisms in the wound and promote the removal of necrotic tissue by macrophages. C) In the immunomodulatory stage, nanomaterials promote the phenotypic transformation of macrophages and regulate the expression of inflammatory factors in the wound. D) During the proliferation and reconstruction stages, nanomaterials promote angiogenesis, granulation tissue hyperplasia, epithelialization, and reorganization of the extracellular matrix.