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\begin{document}

\title{SARS-CoV-2 infection in pregnancy in Denmark -- characteristics and
outcomes after confirmed infection in pregnancy: a nationwide,
prospective, population-based cohort study}



\author[1]{Anna Aabakke}%
\author[2]{Lone Krebs}%
\author[3]{Tanja Petersen}%
\author[3]{Frank Kjeldsen}%
\author[4]{Giulia Corn}%
\author[5]{Karen Wøjdemann}%
\author[6]{Mette Ibsen}%
\author[7]{Fjola Jonsdottir}%
\author[7]{Elisabeth Rønneberg}%
\author[8]{Charlotte Andersen}%
\author[9]{Iben Sundtoft}%
\author[10]{Tine Clausen}%
\author[11]{Julie Milbak}%
\author[12]{Lars Burmester}%
\author[13]{Birgitte Lindved}%
\author[14]{Annette Thorsen-Meyer}%
\author[15]{Mohammed Khalil}%
\author[15]{Birgitte Henriksen}%
\author[16]{Lisbeth Jønsson}%
\author[3]{Lise Lotte Andersen}%
\author[3]{Kamilla Karlsen}%
\author[17]{Monica Pedersen}%
\author[18]{Aase Klemmensen}%
\author[18]{Marianne Vestgaard}%
\author[19]{Dorthe Thisted}%
\author[19]{Manrinder Tatla}%
\author[20]{Line Andersen}%
\author[21]{Anne-Line Brülle}%
\author[21]{Arense Gulbech}%
\author[22]{Charlotte Andersson}%
\author[23]{Richard Farlie}%
\author[24]{Lea Hansen}%
\author[24]{Lone Hvidman}%
\author[25]{Anne Sørensen}%
\author[25]{Sidsel Rathcke}%
\author[26]{Katrine Rubin}%
\author[26]{Lone Petersen}%
\author[3]{Jan Stener Joergensen}%
\author[26]{Lonny Stokholm}%
\author[26]{Mette Bliddal}%
\affil[1]{Copenhagen University Hospital - Holbæk}%
\affil[2]{Amager and Hvidovre Hospital}%
\affil[3]{Odense University Hospital}%
\affil[4]{Statens Serum Institut Afdeling for Epidemiologisk Forskning}%
\affil[5]{Bornholms Hospital}%
\affil[6]{Hospital of Southern Jutland}%
\affil[7]{Herlev Hospital}%
\affil[8]{Herning Hospital}%
\affil[9]{Regional Hospital West Jutland, Herning}%
\affil[10]{Hillerød Hospital}%
\affil[11]{Nordsjællands Hospital}%
\affil[12]{Sygehus Vendsyssel i Hjørring}%
\affil[13]{Horsens Sygehus}%
\affil[14]{Hvidovre Hospital}%
\affil[15]{Kolding Hospital}%
\affil[16]{Nykøbing F Sygehus}%
\affil[17]{Randers Regional Hospital}%
\affil[18]{Copenhagen University Hospital}%
\affil[19]{Zealand University Hospital Roskilde}%
\affil[20]{Slagelse Sygehus}%
\affil[21]{Sygehus Sønderjylland i Aabenraa}%
\affil[22]{Aalborg Universitetshospital}%
\affil[23]{Viborg Regional Hospital}%
\affil[24]{Aarhus University Hospital Skejby}%
\affil[25]{Aalborg University Hospital}%
\affil[26]{University of Southern Denmark Faculty of Health Sciences}%


\vspace{-1em}



  
  \date{May 26, 2024}


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\selectlanguage{english}
\begin{abstract}
Objective To identify risk factors for and outcomes after SARS-CoV-2
infection and severe COVID-19 in pregnancy Design Prospective
population-based cohort study Setting Denmark Population All pregnancies
between 1 March and 31 October 2020 Methods Using data from the Danish
National Patient Register and Danish Microbiology Database and
prospectively registered data from medical records, we compared women
with a positive SARS-CoV-2 test during pregnancy to non-infected
pregnant women. Severe infection was defined as hospital admission due
to COVID-19. Main Outcome Measures Pregnancy, delivery, maternal, and
neonatal outcomes. Results Among 82,682 pregnancies, 418 women had
SARS-CoV-2 infection during pregnancy, corresponding to an incidence of
5.1 per 1000 pregnancies, 23 (5.5\%) of which required hospital
admission due to COVID-19. Risk factors for infection were asthma (OR
2.19 {[}1.41--3.41{]}) and being foreign born (OR 2.12
{[}1.70--2.64{]}). Risk factors for hospital admission due to COVID-19
included obesity (OR 2.74 {[}1.00--7.51{]}), smoking (OR 4.69
{[}1.58--13.90{]}), infection after gestational age in weeks (GA) 22 (GA
22--27: OR 3.77 {[}1.16--12.29{]}; GA 28--36: OR 4.76 {[}1.60--14.12{]})
and having asthma (OR 4.53 {[}1.39--14.79{]}). We found no difference in
any obstetric or neonatal outcomes. Conclusions Severe outcomes of
SARS-CoV-2 infection in pregnancy are rare. Funding The Danish Ministry
of Higher Education and Science (Reg. 0237-00007B) and The Region of
Southern Denmark and Region Zealand's shared fund for joint health
research projects (Reg. A767) Keywords Severe acute respiratory syndrome
coronavirus 2; COVID-19; Obstetric delivery; Pregnancy complications;
Pregnancy outcome; Cohort studies; Prospective studies.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Aabakke et al_Table 3.docx`  available at \url{https://authorea.com/users/730338/articles/710113-sars-cov-2-infection-in-pregnancy-in-denmark-characteristics-and-outcomes-after-confirmed-infection-in-pregnancy-a-nationwide-prospective-population-based-cohort-study}

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