Changes in serum TG level during pregnancy and its association with
postpartum hypertriglyceridemia: a population-based prospective cohort
study
Abstract
Objectives: To characterize triglyceride (TG) changes from pregnancy to
postpartum, associations between them and effects of pre-pregnancy body
mass index (pre-BMI) and gestational diabetes mellitus (GDM). Design:
Prospective cohort study. Setting: FUXING Hospital, Beijing, China.
Population: 908 pregnant women. Methods: Serum lipids at gestational
week 6-8, 16, 24, 36 and 42 days postpartum were measured. Associations
between gestational and postpartum TG were analyzed by stepwise multiple
liner regression, linear mixed-effect model and logistic regression.
Cutoff points were calculated by receiver operating characteristic (ROC)
curves. Main Outcome Measures: hypertriglyceridemia at 42 days
postpartum. Results: TG increased with gestational weeks and decreased
until 42 days postpartum. TGs at 6-8th, 16th, 24th, 36th gestational
week and TG trend of change were positively associated with higher risk
of postpartum hypertriglyceridemia [OR 4.962, 95% CI (3.007-8.189);
OR 3.201, 95% CI (2.222-4.612); OR 2.484, 95% CI (1.853-3.329); OR
1.979, 95% CI (1.597-2.452); OR 11.660, 95% CI (6.018-22.591)].
Serum TG cut-offs were found as 1.12, 1.93, 2.35 and 3.08 mmol/L at
studied gestational week, respectively. The risk of postpartum
hypertriglyceridemia for women with normal pre-BMI and non-GDM was
higher than overweight and obese group and GDM group, respectively.
Conclusions: Gestational TG is a risk factor of postpartum
hypertriglyceridemia, and is more significant among pregnant women with
normal pre-BMI and without GDM. TG measurement and control is essential
during pregnancy. Funding: National Natural Science Foundation of China
(No. 81872608 and No.8207121162). Keywords: TG, Pregnancy, Postpartum,
Hypertriglyceridemia, Pre-BMI, GDM. Tweetable abstract: Gestational TG
increases risk of postpartum hypertriglyceridemia.