Author and publication year Region Study design Type of diseases Number of patients or episodes Comparators Comparators Interested change of items in outcome
Mannitol HTS
Xuecai Huang. 2020
China
RCT, crossover
TBI
n=83; episodes=437
20% mannitol; episodes=221; age: NA; female/male: NA; initial GCS: NA; 10% HTS; episodes=236; age: NA; female/male: NA; initial GCS: NA;
ICP, CPP, MAP, serum sodium, serum osmolarity, CVP
Patil, H. 2019
India
RCT
TBI
n=80; no episode
20%mannitol; n=40; episodes=NA; age: NA; female/male: NA; initial GCS: NA; 3.0%HTS; n=40; episodes=NA; age: NA; female/male: NA; initial GCS: NA;
ICP, CPP, HR, MAP, HCT, serum sodium, serum osmolarity
Jagannatha, A. T. 2016
India
RCT
TBI
n=38; episodes=488
20%mannitol; n=20; episodes=301; age: 31±13a; female/male: 2:18; initial GCS: 5(3-7)b; 3.0%HTS; n=18; episodes=187; age: 27±8a; female/male: 2:16; initial GCS: 4(4-5)b;
ICP, HR, MAP, serum sodium, serum osmolarity, mortality
HUANG Xue. 2015
China
RCT, crossover
SAH
n=25; episodes=196
20%mannitol; n=95; age: NA; female/male: NA; initial GCS: NA; 3.0%HTS; n=101; age: NA; female/male: NA; initial GCS: NA;
ICP, CPP, MAP, serum sodium, serum osmolarity, VP
Cottenceau, V. 2011
France
RCT
TBI
n=47 no episode
20%mannitol; n=25; age: 36.1±16.8 a; female/male: NA; initial GCS: 7(5-8)c; 7.5%HTS; n=22; age: 42.7±19.9 a; female/male: NA; initial GCS: 5(4-7)c;
ICP, CPP, MAP, HCT, serum sodium, CBF, BUN
Sakellaridis, N. 2011
Greece
RCT, crossover
TBI
n=29; episodes=199
20%mannitol; episodes=82; age: NA; female/male: NA; initial GCS: NA 15%HTS; episodes=82; age: NA; female/male: NA; initial GCS: NA;
ICP
Ichai, C. 2008
France
Prospective open randomized study
TBI
n=21; episodes=43
20%mannitol; episodes=18; age: NA; female/male: NA; initial GCS: NA; half-molar sodium lactate; episodes=25; age: NA; female/male: NA; initial GCS: NA;
ICP, CPP
Francony, G. 2008
France
Parallel RCT
TBI, n=17; Stroke, n=3;
n=20; no episode
20%mannitol; n=10; age: 43±11 a; female/male: 3/7; initial GCS: 8±2 a; 7.45%HTS; n=10; age: 37±16 a; female/male: 1/9; initial GCS: 7±2 a;
ICP, serum sodium
Harutjunyan, L. 2005
Germany
RCT
cerebral trauma, spontaneous intracerebral bleeding, SAH
n=32; no episode
15%mannitol; n=15; age: 47±16 a; female/male: 7/8; initial GCS: 5.8±1.4 a; 7.2%NaCl/HES 200/0.5; n=17; age: 47±16 a; female/male: 8/9; initial GCS: 6±1.3 a;
ICP, CPP, HR, MAP, HCT, serum osmolarity
Battison, C. 2005
UK
RCT, crossover
TBI, SAH
n=9; episodes=36
20%mannitol; n=18; age: NA; female/male: NA; initial GCS: NA; 7.5% saline and 6% dextran-70 solution; n=18; age: NA; female/male: NA; initial GCS: NA;
ICP, CPP, MAP, serum sodium, serum osmolarity