|
|
|
|
|
Mannitol |
HTS |
|
Xuecai Huang. 2020
|
China
|
RCT, crossover
|
TBI
|
n=83; episodes=437
|
20% mannitol;
episodes=221;
age: NA;
female/male: NA;
initial GCS: NA;
|
10% HTS;
episodes=236;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP, CPP, MAP, serum sodium, serum osmolarity, CVP
|
Patil, H. 2019
|
India
|
RCT
|
TBI
|
n=80; no episode
|
20%mannitol;
n=40;
episodes=NA;
age: NA;
female/male: NA;
initial GCS: NA;
|
3.0%HTS;
n=40;
episodes=NA;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP, CPP, HR, MAP, HCT, serum sodium, serum osmolarity
|
Jagannatha, A. T. 2016
|
India
|
RCT
|
TBI
|
n=38; episodes=488
|
20%mannitol;
n=20;
episodes=301;
age: 31±13a;
female/male: 2:18;
initial GCS: 5(3-7)b;
|
3.0%HTS;
n=18;
episodes=187;
age: 27±8a;
female/male: 2:16;
initial GCS: 4(4-5)b;
|
ICP, HR, MAP, serum sodium, serum osmolarity, mortality
|
HUANG Xue. 2015
|
China
|
RCT, crossover
|
SAH
|
n=25; episodes=196
|
20%mannitol;
n=95;
age: NA;
female/male: NA;
initial GCS: NA;
|
3.0%HTS;
n=101;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP, CPP, MAP, serum sodium, serum osmolarity, VP
|
Cottenceau, V. 2011
|
France
|
RCT
|
TBI
|
n=47 no episode
|
20%mannitol;
n=25;
age: 36.1±16.8 a;
female/male: NA;
initial GCS: 7(5-8)c;
|
7.5%HTS;
n=22;
age: 42.7±19.9 a;
female/male: NA;
initial GCS: 5(4-7)c;
|
ICP, CPP, MAP, HCT, serum sodium, CBF, BUN
|
Sakellaridis, N. 2011
|
Greece
|
RCT, crossover
|
TBI
|
n=29; episodes=199
|
20%mannitol;
episodes=82;
age: NA;
female/male: NA;
initial GCS: NA
|
15%HTS;
episodes=82;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP
|
Ichai, C. 2008
|
France
|
Prospective open randomized study
|
TBI
|
n=21; episodes=43
|
20%mannitol;
episodes=18;
age: NA;
female/male: NA;
initial GCS: NA;
|
half-molar sodium lactate;
episodes=25;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP, CPP
|
Francony, G. 2008
|
France
|
Parallel RCT
|
TBI, n=17; Stroke, n=3;
|
n=20; no episode
|
20%mannitol;
n=10;
age: 43±11 a;
female/male: 3/7;
initial GCS: 8±2 a;
|
7.45%HTS;
n=10;
age: 37±16 a;
female/male: 1/9;
initial GCS: 7±2 a;
|
ICP, serum sodium
|
Harutjunyan, L. 2005
|
Germany
|
RCT
|
cerebral trauma, spontaneous intracerebral bleeding, SAH
|
n=32; no episode
|
15%mannitol;
n=15;
age: 47±16 a;
female/male: 7/8;
initial GCS: 5.8±1.4 a;
|
7.2%NaCl/HES 200/0.5;
n=17;
age: 47±16 a;
female/male: 8/9;
initial GCS: 6±1.3 a;
|
ICP, CPP, HR, MAP, HCT, serum osmolarity
|
Battison, C. 2005
|
UK
|
RCT, crossover
|
TBI, SAH
|
n=9; episodes=36
|
20%mannitol;
n=18;
age: NA;
female/male: NA;
initial GCS: NA;
|
7.5% saline and 6% dextran-70 solution;
n=18;
age: NA;
female/male: NA;
initial GCS: NA;
|
ICP, CPP, MAP, serum sodium, serum osmolarity
|