CONCLUSION
This study has shown a CNS
dysfunctionality in term LGA neonates. Using a non-invasive, cheap, and
novel electrophysiological technique
–the so-called
frequency-following response (FFR)–, specific deficits in the encoding
of the fundamental frequency of speech, were disclosed. Thus, this study
revealed for the first time perinatal CNS consequences of being born
LGA. The possibility to record the FFR in the maternity ward during the
first days of life, with a routine EEG/ABR system, allows the early
identification of CNS dysfunctionalities in LGA neonates. The FFR could
become part of a screening plan leading to an early intervention
program. The detection of a disrupted FFR could trigger the derivation
to a multidisciplinary expert group who could individualize a
stimulation program and to monitor the progress. Follow-up studies are
needed to determine the extent of these dysfunctionalities and their
predictive value on the infant’s neurodevelopment.