RESULTS
The rat model development has been
confirmed when it mimicked the clinical pathophysiology of futuristic
PTE in Wistar rats (200-250 grams). The brass weight of 500 grams was
dropped over the exposed skull from the height of 1.4 meters. This
impact generated 0.70 joules of force which gives a moderate type of
primary injury in the head. The initial brain insult exacerbated the
epileptogenesis cascade in the form of secondary injury by lowering the
seizure threshold in the Wistar rats and they became susceptible to the
first successive seizure with a sub-convulsive dose of PTZ(35mg/kg).