SUMMARY:
What is already known:
Post-traumatic epilepsy is the most provoking consequence after head trauma with no specific treatment measure.
Epileptogenesis is key term sequelae of altered brain pathophysiology after brain injury for futuristic PTE.
What this study adds
Potential novel targets have been selected for protecting external cytoskeleton and internal cytoplasmic infrastructure.
These proposed targets were tried to perform normal functions with specific potential drug regimens after TBI.
Clinical significance
Fasudil hydrochloride and Flufenamic acid have a significant role to minimize cerebral edema and inflammation.
The combination groups with Valproic acid have been found more effective to minimize epileptogenesis in futuristic PTE.