Study Selection
An initial primary screen was conducted by Authors JW and DJ, to include
only articles in human subjects, articles in English, and articles with
full text availability. Primary screen included carefully reviewing the
database for any duplicates. Furthermore, the primary screen included
exclusion of articles with non-head and neck mucosal melanomas.
A second screen was done to stratify articles according to anatomical
site (Sino nasal or all head and neck), whether they are case reports,
whether treatment outcomes were reported, whether one treatment modality
was used, and whether or not immunotherapy was used. In total, 52
articles met the inclusion criteria, which consisted of 1) treatment
naïve cohorts, 2) those with recurrent disease,3) primary outcomes with
overall survival and disease-free survival at 5 years, and at longest
follow up 4) studies of adults with mucosal melanoma in whom
immunotherapy was reported as a treatment strategy.
The systematic review was conducted and reported in accordance with
PRISMA flow chart (Figure1).