Study Selection
An initial primary screen was conducted by Authors JW and DJ, to include only articles in human subjects, articles in English, and articles with full text availability. Primary screen included carefully reviewing the database for any duplicates. Furthermore, the primary screen included exclusion of articles with non-head and neck mucosal melanomas.
A second screen was done to stratify articles according to anatomical site (Sino nasal or all head and neck), whether they are case reports, whether treatment outcomes were reported, whether one treatment modality was used, and whether or not immunotherapy was used. In total, 52 articles met the inclusion criteria, which consisted of 1) treatment naïve cohorts, 2) those with recurrent disease,3) primary outcomes with overall survival and disease-free survival at 5 years, and at longest follow up 4) studies of adults with mucosal melanoma in whom immunotherapy was reported as a treatment strategy.
The systematic review was conducted and reported in accordance with PRISMA flow chart (Figure1).