CONCLUSION
In this study we present encouraging data on improved survival in immunosuppressed children with AIFR. While still considered one of the deadliest infectious diseases in this population, we observed that low threshold for investigation, utilization of PCR for fungal detection, treatment with novel antifungal agents combined with rapid and aggressive surgical treatment and better control over the underlying oncological disease, dramatically reduced AIFR mortality rates. We suggest that panfungal PCR should have an increasing role in the detection of fungal pathogens and that novel antifungal drugs should become an essential part of the treatment regimen.