KEY POINTS
- The survival of immunosuppressed children with acute invasive fungal
rhinosinusitis (AIFR) has improved dramatically over the past decade.
- No patient has died of AIFR since 2012.
- Utilization of PCR for fungal detection was associated with
significantly improved fungal detection rate.
- Panfungal PCR along with treatment with novel antifungal medications
were associated with improved survival.
- Low threshold for investigation, rapid and aggressive surgical
treatment, and better control over the underlying oncological disease
are also crucial for improved AIFR-specific survival.