Corresponding author:
Yunliang Guo, Institute of Cerebrovascular Diseases, Medical Research
Center, the Affiliated Hospital of Qingdao University, Qingdao 266000,
China. Email: guoqdsd@qdu.edu.cn.
Yumin Luo, Cerebrovascular Diseases Research Institute and Department of
Neurology, Xuanwu Hospital of Capital Medical University, Beijing
100053, China. Email: yumin111@ccmu.edu.cn. ORCID iD: Yumin Luo,
https://orcid.org/0000-0002-2712-8974
Word count: 4154 words
Acknowledgements:National Natural Science
Foundation Youth Fund grant number (81901194 and 82001268); We would
like to thank Editage (www.editage.cn) for English language editing.
Conflicts of interest: None.
Author contribution: G.L.
and X.M. conducted study design, animal experiments, histology
experiment, and manuscript preparation. H.Z., J.F. and T.L. designed
clinical experiment. Y.L. and Y.G. designed and managed the research.
Declaration of transparency and scientific rigour This Declaration acknowledges that this paper adheres to the principles
for transparent reporting and scientific rigour of preclinical research
as stated in the BJP guidelines for Design & Analysis, Immunoblotting
and Immunochemistry, and Animal Experimentation, and as recommended by
funding agencies, publishers and other organizations engaged with
supporting research.