Key Results
There was H19 and C1QTNF6 upregulation, as well as miR-29b downregulation, in neutrophils of patients with stroke. Moreover, miR-29b could bind C1QTNF6 mRNA to repress its expression while H19 could sponge miR-29b to maintain C1QTNF6 expression. Moreover, C1QTNF6 overexpression promoted the release of IL-1β and TNF-α in leukocytes and further exacerbates blood-brain barrier disruption.