Corresponding author:
Yunliang Guo, Institute of Cerebrovascular Diseases, Medical Research Center, the Affiliated Hospital of Qingdao University, Qingdao 266000, China. Email: guoqdsd@qdu.edu.cn.
Yumin Luo, Cerebrovascular Diseases Research Institute and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China. Email: yumin111@ccmu.edu.cn. ORCID iD: Yumin Luo, https://orcid.org/0000-0002-2712-8974
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Acknowledgements:National Natural Science Foundation Youth Fund grant number (81901194 and 82001268); We would like to thank Editage (www.editage.cn) for English language editing.
Conflicts of interest: None.
Author contribution: G.L. and X.M. conducted study design, animal experiments, histology experiment, and manuscript preparation. H.Z., J.F. and T.L. designed clinical experiment. Y.L. and Y.G. designed and managed the research.
Declaration of transparency and scientific rigour This Declaration acknowledges that this paper adheres to the principles for transparent reporting and scientific rigour of preclinical research as stated in the BJP guidelines for Design & Analysis, Immunoblotting and Immunochemistry, and Animal Experimentation, and as recommended by funding agencies, publishers and other organizations engaged with supporting research.