Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment

Zhongjian Wang ^{a, 1}, Wei Liu ^{b, 1}, Xueyan Li ^b, Hongjiao Chen ^b, Dongying Qi ^b, Fulu Pan ^b, Huining Liu ^b, Shuang Yu ^b, Guopeng Wang^c, *, Yang Liu ^b, *

^a Pharnexcloud Digital Technology Co., Ltd., Chengdu, Sichuan, 610093, China

^bSchool of Chinese Materia Medica , Beijing University of Chinese Medicine, Beijing 100102, China

^c Zhongcai Health (Beijing) Biological Technology Development Co., Ltd., Beijing 101500, China

*Correspondence to:

GuoPeng Wang

Zhongcai Health (Beijing) Biological Technology Development Co., Ltd., Xingsheng South Road, Miyun District, Beijing101520, China.

Tel: +86 13520841839; E-mail address: binglelly@163.com.

Yang Liu

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing102488, China.

Tel: +86 13810283092; E-mail address: liuyang@bucm.edu.cn.

¹ These authors contributed equally to this work.