Figure legends
Figure 1: The ligand-binding patterns of the seven-transmembrane domain G-protein-coupled chemokine receptors.
Figure 2: Biological functions of CCL21/CCR7 chemokine axis.
Figure 3: Regulation of CCL21/CCR7 chemokine axis on immune cells. CCL21/CCR7 chemokine axis has been found to regulate the functions and activities of immune cells, to balance immune cell subsets, which could further reduce inflammation and tissue damage in autoimmune diseases.
Figure 4: Effects of CCL21/CCR7 chemokine axis on MAPKs signaling pathway, PI3K/AKT signaling pathway and Smads signaling pathway in autoimmune diseases. MAPKs, PI3K/Akt and Smads signaling mediated by CCL21/CCR7 chemokine axis participates in the occurrence and development of autoimmune diseases.
F igure 5: Effect of CCL21/CCR7 chemokine axis on autoimmune diseases-related indicators. CCL21/CCR7 chemokine axis is widely involved in the pathological process of autoimmune diseases, including RA, SS, SLE, PM, AS and so on, through regulating inflammatory cytokines and disease-related indicators, and mediating signaling pathways.