Figure legends
Figure 1: The ligand-binding patterns of the
seven-transmembrane domain G-protein-coupled chemokine receptors.
Figure 2: Biological functions of CCL21/CCR7 chemokine axis.
Figure 3: Regulation of CCL21/CCR7 chemokine axis on immune
cells. CCL21/CCR7 chemokine axis has been found to regulate the
functions and activities of immune cells, to balance immune cell
subsets, which could further reduce inflammation and tissue damage in
autoimmune diseases.
Figure 4: Effects of CCL21/CCR7 chemokine axis on MAPKs
signaling pathway, PI3K/AKT signaling pathway and Smads signaling
pathway in autoimmune diseases. MAPKs, PI3K/Akt and Smads signaling
mediated by CCL21/CCR7 chemokine axis participates in the occurrence and
development of autoimmune diseases.
F igure 5: Effect
of CCL21/CCR7 chemokine axis on autoimmune diseases-related indicators.
CCL21/CCR7 chemokine axis is widely involved in the pathological process
of autoimmune diseases, including RA, SS, SLE, PM, AS and so on, through
regulating inflammatory cytokines and disease-related indicators, and
mediating signaling pathways.