Conclusion and future perspective
In summary, the specific combination of CCL21 and CCR7 significantly
promotes the activity of immune cells, induces immune cell homing and
promotes immune cell migration and angiogenesis during the process of
immunity and inflammation. The migration of immune cells is a crucial
part of the autoimmune response. Accordingly, the pathological role of
CCL21 and CCR7 has attracted more and more attention from domestic and
foreign scholars in autoimmune diseases (Rizeq et al., 2020)(Figure 5).
With the in-depth exploration of CCL21/CCR7 chemokine axis, it was found
that CCL21 and CCR7 regulate the expression of downstream proteins
through the activation of intracellular signaling pathways to promote
the migration of immune cells to inflammatory and infectious sites,
which participates in the occurrence and development of autoimmune
diseases (McHugh, 2019). Therefore, understanding the signaling
transduction mechanism of CCL21 and CCR7 in autoimmune diseases is
essential for the discovery of potential diagnostic biomarkers and
therapeutic targets, providing a deep foundation and new insights for
the development of new drugs. Therefore, it is of great significance to
elucidate the important role of CCL21/CCR7 chemokine axis in
inflammatory response for reveal the pathological mechanism of
autoimmune diseases and discovering new biomarkers and new drug targets.