Cell adhesion and integration capabilities of CCL21/CCR7
chemokine axis
CCL21/CCR7 chemokine axis has the ability to promote cell adhesion and
affinity to varying degrees. Previous studies have found that CCL21/CCR7
chemokine axis can enhance the adhesion properties of glomerular
mesangial cells through mediating glycogen synthase kinase 3 (GSK3) and
Akt pathways (Li et al., 2011). CCL21/CCR7 chemokine axis can also
promote the metabolism, adhesion and anti-apoptotic processes of various
tumor cells. In metastatic squamous cell carcinoma of the head and neck,
CCL19/CCR7 chemokine axis promotes the migration of tumor cells by
regulating β1 integrin expression. Subsequently, studies
have also discovered that integrin αvβ3, a new signaling molecule, is
involved in the process of tumor cell migration through CCL19/CCR7
chemokine axis. These signaling molecules initiate the process of cell
adhesion and migration through the interaction with the CCL21/CCR7
chemokine axis (Zhang et al., 2018).