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\begin{document}

\title{Percentiles of intrauterine placental volume and placental volume
relative to fetal volume: A prospective magnetic resonance imaging study}



\author[1]{Helene Peterson}%
\author[1]{Anne Eskild}%
\author[1]{Silje Sommerfelt}%
\author[1]{Kjell Gjesdal}%
\author[1]{Arne Borthne}%
\author[2]{Lars Mørkrid}%
\author[1]{Vigdis Hillestad}%
\affil[1]{Akershus University Hospital}%
\affil[2]{Oslo University Hospital}%


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  \date{May 27, 2024}


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\begin{abstract}
Objective: Provide normative data on intrauterine placental size and
placental size relative to fetal size (placental to fetal ratio).
Design: Prospective study. Setting: Akershus University Hospital,
Norway. From April 2017 to May 2018. Population: 107 unselected
singleton pregnancies recruited at routine antenatal care. Method: The
pregnancies were examined by magnetic resonance imaging (MRI) at
gestational week 27 and 37. Based on the estimated volumes of the
placenta and the fetus, we calculated median and percentiles at the
gestational weeks 27 and 37, and we assumed linear growth in the
intermediate interval. Main outcome measures: Median placental volume
(cm3) and placental to fetal ratio (placental volume cm3/fetal volume
cm3). Results: Median placental volume at gestational week 27 was 513
cm3 (Inter Quartile Range (IQR) 182 cm3), and it was 831cm3 (IQR 252
cm3) at week 37. Median placental to fetal ratio was 0.54 (IQR 0.18) at
gestational week 27 and 0.31 (IQR 0.08) at week 37. The 10th -- 90th
percentiles included placental volumes between 392-717 cm3 at
gestational week 27, and 631-1087 cm3 at week 37. The corresponding
10th-90th percentiles included placental to fetal ratios between
0.43-0.73 and 0.25-0.39. Conclusions: This study provides normative data
about intrauterine placental volume and placental volume relative to
fetal volume. Such data are important for the diagnostics of abnormal
growth. Funding: The South-Eastern Norway Regional Health Authority
(grant number 277901 and 2020013) and the Strategic Research Funding at
Akershus University Hospital (grant number 269903). Keywords: Placenta,
placental to fetal ratio MRI, pregnancy, percentiles%
\end{abstract}%



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