Receptor Affinity (nM) Function Reference
CB1 Ki = 3.3~4.9 microM Inverse agonist/antagonist (Tham et al., 2019; Thomas et al., 2007)
IC50 = 0.27-0.96 microM Negative allosteric modulators (Laprairie et al., 2015)
CB2 Ki = 4.3 μM Antagonist (Martínez-Pinilla et al., 2017)
EC50 = 503 nM Inverse agonist (Thomas et al., 2007)
IC50 = 3 nM Negative allosteric modulators (Martínez-Pinilla et al., 2017)
GPR55 IC50 = 445 nM Antagonist (Ryberg et al., 2007)
TPPA1 EC50 = 110 nM Agonist (Luciano De Petrocellis et al., 2011)
TRPV1 EC50 = 1000 nM Agonist (Bisogno et al., 2001; Luciano De Petrocellis et al., 2011)
TRPV2 EC50 = 1250 nM Agonist (Luciano De Petrocellis et al., 2011)
TRPV3 EC50 = 3700 nM Agonist (L. De Petrocellis et al., 2012)
TRPV4 EC50 = 800 nM Agonist (L. De Petrocellis et al., 2012)
TRPM8 IC50 = 160 nM Antagonist (Luciano De Petrocellis et al., 2008)
5-HT1A N.D Indirect agonist (Ethan B. Russo et al., 2005)
PPARγ EC50 = 2010 nM Agonist (Granja et al., 2012)
FAAH 27.5 μM Inhibitor (Bisogno et al., 2001; Elmes et al., 2015)
D2
Ki= 11 nM at D2High Ki = 2800 nm at D2Low
Partial agonist
(Ryberg et al., 2007)