ACKNOWLEDGEMENTS
This research has been conducted using the UK Biobank Resource under Application (no. 51671). We thank all participants and study staff of UK Biobank.
STATEMENT OF INTERESTS: None
FUNDING: This work was supported by the National Natural Science Foundation of China (82003408, 82003524, 82060511 and 82103913), the Startup Fund for the 100 Top Talents Program, SYSU (392012). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.