|
Regular PPI use |
Regular PPI use |
|
No |
Yes |
Number of participants*
|
425843 |
46530 |
Mean (SD) Age, years |
56.5 (8.11) |
59.9 (7.29) |
Male |
196435 (46.1%) |
21058 (45.3%) |
N (%) White |
402225 (94.5%) |
44250 (95.1%) |
Mean (SD) Index of multiple deprivation |
17.1 (13.9) |
20.0
(15.8) |
Smoking status |
|
|
Current |
44839 (10.5%) |
5328 (11.5%) |
Previous |
141956 (33.3%) |
19281 (41.4%) |
Never |
239048 (56.1%) |
21921 (47.1%) |
Alcohol consumption |
|
|
Daily or almost daily |
87605 (20.6%) |
8213 (17.7%) |
One to four times a week |
210968 (49.5%) |
19949
(42.9%) |
One to three times a month |
48492 (11.4%) |
5471
(11.8%) |
Special occasions only or never |
78778 (18.5%) |
12897
(27.7%) |
Physical activity |
|
|
Low |
62645 (14.7%) |
8625 (18.5%) |
Moderate |
140208 (32.9%) |
13913 (29.9%) |
High |
140908 (33.1%) |
12585 (27.0%) |
Mean (SD) fruit and vegetable intake |
4.62 (3.09) |
4.61
(3.21) |
Mean (SD) red and process meat intake (times/week) |
2.81 (1.13) |
2.88
(1.11) |
Mean (SD) sleep time (hour) |
8.13 (1.12) |
8.09 (1.37) |
BMI |
27.2 (4.69) |
29.2 (5.13) |
Multivitamin use |
62113 (14.6%) |
8166 (17.5%) |
Intake of mineral supplements |
91120 (21.4%) |
9561
(20.5%) |
Mean (SD) systolic blood pressure (mm hg) |
139 (19.7) |
142
(19.1) |
Hyperlipidemia |
212875 (50.0%) |
32352 (69.5%) |
Diabetes |
23088 (5.4%) |
5404 (11.6%) |
CVD |
24027 (5.6%) |
8832 (19.0%) |
Esophagitis/barretts esophagus |
2356 (0.6%) |
4092
(8.8%) |
Gastroesophageal reflux disease |
8938 (2.1%) |
18720
(40.2%) |
Peptic ulcer |
4358 (1.0%) |
5774 (12.4%) |
Upper gastrointestinal bleeding |
2217 (0.5%) |
1397
(3.0%) |
Overall health rating |
|
|
Poor |
13688 (3.2%) |
6259 (13.5%) |
Fair |
80121 (18.8%) |
16714 (35.9%) |
Good |
255332 (60.0%) |
21292 (45.8%) |
Excellent |
76702 (18.0%) |
2265 (4.9%) |
Longstanding illness |
117678 (27.6%) |
27350 (58.8%) |
Aspirin use |
55564 (13.0%) |
11398 (24.5%) |
Non-aspirin NSAIDs use |
69163 (16.2%) |
8039 (17.3%) |
Paracetamol use |
89671 (21.1%) |
15323 (32.9%) |
ACEIs use |
37531 (8.8%) |
8250 (17.7%) |
ARBs use |
9872 (2.3%) |
2712 (5.8%) |
Beta-blockers use |
23290 (5.5%) |
6452 (13.9%) |
Calcium channel blockers use |
23416 (5.5%) |
5406
(11.6%) |
Thiazide diuretics use |
23949 (5.6%) |
4870 (10.5%) |
Metformin use |
10747 (2.5%) |
2711 (5.8%) |
Statin use |
60405 (14.2%) |
15226 (32.7%) |
H2RAs use |
7669 (1.8%) |
2098
(4.5%) |
Anticoagulants/antiplatelets use |
6063 (1.4%) |
2412
(5.2%) |