2.9 Numerical Modeling
We used COMSOL Multiphysics 5.6 to simulate electric field gradient and
determined the DEP regions in the microfluidic chip where U87 glioma
cells were introduced. Figure 3 illustrates the simulated
microelectrode array using the Electric Current and Creeping Flow
modules to determine the distribution of the electric field gradient
(\(\nabla E^{2})\). We applied 3 Vpp electric potential
(-1.5 Vpp and +1.5 Vpp) to the gold
electrodes as indicated in Figure 3 . We chose both the
Stationery and Frequency Domain Study solvers. We used the dynamic
viscosity (8.94E-4 Pa.s), density (1000 kg/m3),
permittivity (\(\varepsilon_{0},\ 80\)), and conductivity (\(\sigma\),
20 µS/cm) values of the DEP buffer properties in the model.