CONCLUSION
In general, in hospitals in Brazil there are specific circumstances that
interfere in the variation in the consumption of antifungal agents in
the ICU, such as the profile of strains’ sensitivity to antifungal
agents, the prescription practices and the epidemiology of the IFIs,
which despite not being included in this study, influence the
consumption of these agents. The vast majority of studies greatly
reinforce the pattern of consumption of antimicrobials, emphasizing
antibacterials, and this limits the number of studies that serve to
counteract the results for systemic antifungal agents. Therefore,
observing the variation in the consumption of these drugs helps to
better assess the dispensing process and, consequently, their rational
use. This pharmacoepidemiology practice, widely used in Europe in drug
use studies, it is important not only for the knowledge and monitoring
of adverse reactions and consumption, but also for the rationing of
hospital expenses. According to the data, fluconazole showed a smaller
growth trend in relation to the other studies compared, but it was still
considered the most consumed drug in the analyzed period, different from
itraconazole, which, with a reduced consumption density, was not very
expressive in terms of use in the ICU, and voriconazole presented a
growing scale of consumption, which shows its use in fungal infections
in this sector.