Tweetable abstract
By measuring the relative expression of TRPV1, KATP subtype SUR2B/Kir6.1 and nitric oxide synthase (eNOS) in the placental arteriosa in normal pregnancy and severe preeclampsia and by culturing human umbilical vein endothelial cellsĀ and measuring the relative expression of TRPV1, SUR2B/Kir6.1 and eNOS after the addition of TRPV1 agonists and inhibitors, the results showed thatĀ TRPV1 combined with the downregulation of KATP expression downregulates the expression of eNOS, reducing the synthesis and release of NO and reducing vasodilation, which may be critical in the pathogenesis of severe preeclampsia.