Discussion
Hodgkin’s lymphoma is a type of blood cancer that responds to treatment. This type of disease is considered uncommon. Chemotherapy is the first line in controlling this disease. In the advanced stages of the disease and in recurrent cases, a bone marrow transplant may be performed to control the disease[18].
In general, marrow transplantation is divided into two main types according to the source of stem cells, which are autologous bone marrow transplantation where stem cells from patient and allogeneic bone marrow transplantation, from a donor. There are many chemotherapeutic protocols prior to marrow transplantation, in order to prepare the bone to receive stem cells. These chemical protocols are in high doses and cause many complications, including neutropenia and neutropenic fever[19].
One of the treatments used in the treatment of neutropenic fever is the liposomal Amphotericin-B (Ambisome)[10].
A hypersensitivity reaction to liposomal Amphotericin has been reported in many cases [20-24]. This is the first case to report hypersensitivity to liposomal Amphotericin-B (Ambisome) in patients with bone marrow transplantation in bone marrow transplant center, Iraq. The allergy occurred from the first dose that was given to the patient, and the situation was corrected by giving some medications that reduced the sensitivity and improved the patient’s condition. Although this is the first case of an allergic reaction to liposomal Amphotericin-B recorded in our center, great care must be taken in patients who take Liposomal Amphotericin-B, especially in the first dose.
The approval of the bone marrow transplant center and the patient was obtained in order to publish this data and study.