Association of SLC polymorphisms with gender and OS
In lung carcinoma patients, 83.2% (404) of males and 82.4% (89) of
females were dead at the time of analysis. Males having SLC19A1
G80A polymorphism and possessing heterozygous
genotype (GA ) showed reduced survival as compared to the subjects
harboring wild-type alleles (GG ) (MST=7.13 versus 7.9 months; HR=
1.1; log-rank p=0.38). After using multivariate analysis and adjusting
for factors such as age, smoking, stage, histology, KPS, ECOG, the death
risk increased to 1.26 times in heterozygous genotype (GA ) as
compared to the wild type (GG ) genotype (HR=1.26, 95%
CI=0.99-1.61; p=0.05 ). Also, forSLCO1B1A388G polymorphism, in the co-dominant
model, lower survival was observed in the males having mutant genotype
(GG ) as compared to the subjects harboring wild type genotype
(AA ) (MST=7.57 versus 7.7 months; HR=1.35, 95% CI=1.01-1.81;
p=0.04 ) as shown in Supplementary Table 3 . However, we
did not find any significant association of SLC polymorphism in females
with overall survival. We also evaluated the survival differences in
lung cancer patients according to age; however, no significant
association was found between SLC polymorphisms and overall survival
(Data not shown)