Genotypic distribution of SLC variants
For SLC19A1 G80A polymorphism, 195(31.9%)
patients were homozygous for the GG genotype, 131 (21.4%)
patients were homozygous for the AA genotype, whereas 284
(46.5%) patients were heterozygous (GA ) (Table 2).While for SLCO1B1 A388G polymorphism, 152
(24.9%) patients were harboring homozygous AA genotype, 297
(48.6%) were heterozygous AG , and 161 (26.3%) were homozygoteGG variant whereas, for SLCO1B1 T521C ,
563 (92.2%) patients were homozygous for TT genotype, 45 (7.3%)
patients harbored heterozygous (TC) genotype and 2 (0.32%) individuals
had homozygous (CC ) genotype. For the SLCO1B3
A1683-5676G variant, 545 (89.34%) patients were
harboring homozygous AA genotype, 64 (10.4%) were heterozygousAG , and 1 (0.16%) were homozygote GG variant. The
genotypic frequencies for SLC19A1 G80A was
(χ2=2.08,df=2; p=0.14). The genotypic frequencies of SLCO1B1
A388G (χ2=0.41,df=2; p=0.52) and SLCO1B1
T521C polymorphism was (χ2=1.13, df=2; p=0.28)
whereas for SLCO1B3 A1683-5676G genotypic
frequency was χ2=0.38,df=2; p=0.53. Therefore, genotypic distribution
for these four polymorphic sites followed the Hardy-Weinberg equilibrium
with a p-value> 0.05, as shown in table 2. So,
these samples could be a Mendelian population in a state of genetic
equilibrium.