Patients’ characteristicsÂ
A total of 10 patients were treated with nebulized voriconazole during
the study period, data is shown in Table 2. There were 9 adults and one
paediatric patient; the median age was 35 (5-69) and all of them were
male. Five patients were affected by CF and 8 had received at least one
LT, the median time from LT was 7 (0-84) months (3 CF patients had
received LT).
Fungi detected were mainly Aspergillus spp. (5; 50%), beingA. flavus the most common (4; 40%), followed byScedosporium spp. (4; 40%). Respiratory distress was
present in 6 patients (6; 60%), there were two cases of fungal
colonization (2; 20%) and one asymptomatic patient. One patient
received nebulized voriconazole as fungal prophylaxis after LT after
multi-resistant Scedosporium prolificans had been isolated from
the graft transportation fluid.