Voriconazole solution compounding and characterization
Voriconazole vials containing 200 mg of powder for solution for infusion
were diluted with 19ml of sterile water for injection; syringes
containing 40 mg of voriconazole in 4ml were obtained. Voriconazole
powder from Teva® was diluted in sodium chloride 0.9% in order to reach
an acceptable osmolarity. Characterization of the compounded
voriconazole solutions is shown in Table 1, all of them were considered
appropriate for nebulization based on published literature (12-17).
It was estimated that the voriconazole solution was chemically stable
for 30 days refrigerated (2-8ºC) and 90 days frozen (-20ºC) (11, 13).
Biological stability was calculated based on the Good Manufacturing
Practice in Hospital Pharmacy Services (13), since it was shorter, it
defined the voriconazole solution valid period as 9 days refrigerated
and 45 days frozen.