Statistical analysis
The frequency of cardiovascular events according to type of osteoporosis drug was compared using Fisher’s exact test. The reporting odds ratio (ROR), which can identify drug-associated adverse events, 95% confidence interval (CI), and P-values were calculated. Multivariate logistic analysis was then used to identify cardiac events and cerebrovascular events in romosozumab users. Sex, age ≥80 years, and presence of cardiac disease, cerebrovascular disease, hypertension, and diabetes were included in the analysis. Modelling was based on a complete-case analysis. Odds ratio (OR), 95% CI, and P-values were calculated. All analyses were performed using R version 4.1.2 (R Foundation for Statistical Computing, Vienna, Austria). A P-value < 0.05 was considered statistically significant.