Statistical analysis
The frequency of cardiovascular events according to type of osteoporosis
drug was compared using Fisher’s exact test. The reporting odds ratio
(ROR), which can identify drug-associated adverse events, 95%
confidence interval (CI), and P-values were calculated. Multivariate
logistic analysis was then used to identify cardiac events and
cerebrovascular events in romosozumab users. Sex, age ≥80 years, and
presence of cardiac disease, cerebrovascular disease, hypertension, and
diabetes were included in the analysis. Modelling was based on a
complete-case analysis. Odds ratio (OR), 95% CI, and P-values were
calculated. All analyses were performed using R version 4.1.2 (R
Foundation for Statistical Computing, Vienna, Austria). A P-value
< 0.05 was considered statistically significant.