In active volcanic systems, the elevated pressurization of fluids and the movement of melt materials have an enormous influence on the stress-state of rocks and their mechanical behavior. We use seismic ambient noise to evaluate the static seismic velocity variations related to long-term volcanic deformation, and the dynamic changes associated with the 2017 Casamicciola earthquake (Mw 3.9), in the active volcanic complex of the Ischia Island (Italy). Our study reveals a significant dynamic velocity reduction mostly related to the near-surface damage, with a permanent drop near the red zone, that we posit to be related to the documented landslides and the subsidence observed immediately after the earthquake. We also report a positive long-term linear trend of velocity variations, sensitive to a generalized contraction of the Ischia Caldera that we revealed with geodetic modeling. Our results suggest a depressurization of the shallow hydrothermal system, through degassing along faults or sills.