Abstract
Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm
defined by dysregulated and uncontrolled proliferation of mature and
maturing granulocytes with uniform distribution. It is associated with
the fusion of BCR (on chromosome 22) and ABL1 (on chromosome 9)
resulting in a BCR: ABL1 fusion gene. This fusion gene produces BCR:
ABL1 protein which causes the constitutive activation of Tyrosine
kinase, implicated in the pathogenesis of chronic myelogenous leukemia.
The Morel Lavallee lesion is a closed soft tissue degloving injury
resulting from the separation of the hypodermis from the underlying
fascia, which in turn leads to hematoma collection between the layers.
It is a rare manifestation of chronic myelogenous leukemia (CML). In
this report, we describe a 50-year-old female who presented with right
abdominal swelling, associated with easy fatigability, and significant
weight loss of 1 month. Later confirmed to be chronic myelogenous
leukemia with bone marrow aspiration and BCR/ABL1 fusion mRNA by RT-PCR.
Keywords: chronic myelogenous leukemia, myeloproliferative neoplasm,
Morel Lavallee, BCR/ABL1