Parameter Description Estimateint. (CV%) Estimatefinal (CV%) IIV[%] (CV%) Shrinkage
ktra [h-1] Transit rate constant for a 150 mg dose 0.114 (12) 0.117 (13) 31.2 (33) 9.7%
\(\tau_{0}\) [h] Duration of 0-order absorption process 1.33 (15) 1.24 (14) 51.9 (30) 6.4%
Fr Fraction of dose absorbed through 0-order process 0.270 (15) 0.318 (13) 57.4 (27) 0.99%
CL/Fa [L/h] Apparent total clearance for a 150 mg dose 35.2 (8) 35.4 (6.8) 25.3 (29) 3.3%
Q/F [L/h] Apparent intercompartmental clearance 58.2 (51) 65.1 (47) - -
V/F [L] Apparent distribution volume of the central compartment 274 (7.1) 347 (6.3) - -
V2/F [L] Apparent distribution volume of the peripheral compartment 154 (16) 144 (16) - -
ktrCLDosea Covariate effect of dose on ktr and CL -0.473 (21) -0.430 (24) - -
BL [°C] Baseline effect; intercept of the linear correlation between plasma concentration and effect 36.7 (0.5) 36.7 (0.7) - -
SL [°C∙L∙µg-1] Slope of linear correlation between plasma concentration and effect 0.0421 (11) 0.0418 (13) 56.7 (29) 3.5%
ERRC Proportional error for the observed plasma concentrations 0.195 (3.6) 0.204 (4.0) - -
ERRE Proportional error for the observed effect measures 0.0548 (4.1) 0.0550 (4.9) - -
Secondary parameters Secondary parameters Secondary parameters Secondary parameters Secondary parameters
ke [h-1] Elimination rate constant = CL / V - 0.102 (8.6) - -
MTT [h] Mean transit time = 2 / ktr - 17.1 (13) - -
t½ [h] Elimination half-life = ln(2) / ke - 6.80 (8.6) - -
k0 [h-1] 0-order absorption rate constant = 1 / \(\tau_{0}\) - 0.808 (14) - -