ktra
[h-1] |
Transit rate constant for a 150 mg dose |
0.114 (12) |
0.117 (13) |
31.2 (33) |
9.7% |
\(\tau_{0}\) [h] |
Duration of 0-order absorption process |
1.33
(15) |
1.24 (14) |
51.9 (30) |
6.4% |
Fr |
Fraction of dose absorbed through 0-order process |
0.270 (15) |
0.318 (13) |
57.4 (27) |
0.99% |
CL/Fa [L/h] |
Apparent total clearance for a 150
mg dose |
35.2 (8) |
35.4 (6.8) |
25.3 (29) |
3.3% |
Q/F [L/h] |
Apparent intercompartmental clearance |
58.2 (51) |
65.1
(47) |
- |
- |
V/F [L] |
Apparent distribution volume of the central compartment |
274 (7.1) |
347 (6.3) |
- |
- |
V2/F [L] |
Apparent distribution volume of the peripheral
compartment |
154 (16) |
144 (16) |
- |
- |
ktrCLDosea
|
Covariate effect of dose on ktr and CL |
-0.473
(21) |
-0.430 (24) |
- |
- |
BL [°C] |
Baseline effect; intercept of the linear correlation
between plasma concentration and effect |
36.7 (0.5) |
36.7 (0.7) |
- |
- |
SL [°C∙L∙µg-1] |
Slope of linear correlation
between plasma concentration and effect |
0.0421 (11) |
0.0418 (13) |
56.7 (29) |
3.5% |
ERRC
|
Proportional error for the observed plasma
concentrations |
0.195 (3.6) |
0.204 (4.0) |
- |
- |
ERRE
|
Proportional error for the observed effect
measures |
0.0548 (4.1) |
0.0550 (4.9) |
- |
- |
Secondary parameters |
Secondary parameters |
Secondary parameters |
Secondary parameters |
Secondary parameters |
|
ke [h-1] |
Elimination rate
constant = CL / V |
- |
0.102 (8.6) |
- |
- |
MTT [h] |
Mean transit time = 2 /
ktr
|
- |
17.1 (13) |
- |
- |
t½ [h] |
Elimination half-life = ln(2) /
ke
|
- |
6.80 (8.6) |
- |
- |
k0 [h-1] |
0-order
absorption rate constant = 1 / \(\tau_{0}\)
|
- |
0.808 (14) |
- |
- |