The mRNA expression of SPRING1 in B-ALL patients
We examined the mRNA expression level of SPRING1 in 20 B-ALL
patients and 20 non-malignant ITP cases by comparative qRT-PCR. The
qRT-PCR data are demonstrated as a box plot in Fig. 3A based on the log2
FC of mRNA expression level. A significant upregulation ofSPRING1 (80%) was detected in B-ALL patients. The mean FC ofSPRING1 was 3.21 in patients. Moreover, RNA-seq data revealed the
upregulation of SPRING1 in B-ALL patients compared to ITP
samples, as shown in Fig. 3B. Interestingly, the SPRING1expression level is increased in B-ALL patients compared to ITP based on
both in-silico and qRT-PCR data.