Data resource
RNA-seq data profiles were obtained from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/). These data profiles have included 69 B-ALL and 12 ITP samples from three different projects, including PRJNA397402, PRJNA475264, and PRJNA549254 . Moreover, we performed RNA-seq analysis for 10 Iranian B-ALL and 2 ITP samples, and the raw RNA-seq data is available under accession number PRJNA589314. Data profiles and the number of samples are indicated in Table 1. FASTQ raw data were trimmed by Trimmomatic software and mapped to the human reference genome (GRCh38/hg38) using STAR (version: 2.7.3a). Then, HTSeq-count (version: 1.99.2) was utilized for gene quantification and DEGs were identified by the DESeq2 package in the R environment (version 4.0.5). A │log2 fold change (FC)│ > 2 with P -adjusted values < 0.05 and baseMean > 100 was considered significant for validating DEGs .