Patients and ethics statement
Bone marrow mononuclear cells (BMMNCs) samples were obtained from 20 B-ALL patients and 20 non-malignant ITP (immune thrombocytopenic purpura) patients who had not received any chemoradiotherapy before aspiration and had no history of any cancer type, respectively. Specimens were obtained from Dr. Sheikh Children’s Hospital of Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. All individual participants signed informed consent forms prior to their inclusion in the study. The ethics committee of the Ferdowsi University of Mashhad, Mashhad, Iran approved the research protocol (ethical code: IR.UM.REC.1400.058) and it was performed following the Helsinki Declaration.