Figure 6. Genes and pathways analysis in mice with arginase high expression. (A) Gene set enrichment analysis (GSEA) comparing gene-expression data from mouse tumor tissue and that treated with LPS. GSEA of the Hallmark ‘ECM receptor interaction’ (B) and ‘IL-2-JAK-STAT Signaling’ (C) pathway in mice tumor tissue.
Arginase is a key enzyme in tumor-associated macrophages (TAMs) and plays an important role in TAM-mediated immune evasion, but its in-situ variation and relevant mechanism are unclear. In this work, dynamic changing of arginase in TAMs is observed during immune evasion of HCC. Results reveal that arginase initiates proline production and then activates tumor-associated fibroblasts, enhancing immune evasion in HCC.
Keywords: Fluorescent probe, Arginase, Tumor-associated macrophages, Immune evasion, Tumor-associated fibroblasts
Chuanchen Wu, Yuantao Mao, Xinru Qi, Xin Wang, Ping Li, * Wen Zhang and Bo Tang *