Author contributions
DK Zheng, CH Cheng and YH Tang contributed to statistical analyses and manuscript writing. ZX Fang and YH Tang contributed to interpretation of the data. YC Chen, QH You, and XL Gao helped with collecting tissues from the mice. KF Wang, HQ Zhou, and ZX Lan provided advice and revised the manuscript. J Sun contributed to the study concept and design, critical revision of the manuscript, and administrative support. All of the authors critically reviewed and approved the final version of the manuscript.