Definitions
Complete viral suppression was defined as HBV DNA levels below the detection limit or undetectable for more than 12 months. ALT levels exceeding 35 U/mL in males and 25 U/mL in females were defined as ALT elevation.14 In this study, the serum ALT elevation at all visits was defined as PeALT. If the ALT level was normal at all visits, it was defined as persistently normal ALT (PnALT).