Figure 6. The effects of vortioxetine (VOR) and duloxetine (DLX) treatment on the mRNA expression of Il -1β, Tnf-α, Ngf, Bdnf andTac1 in the dorsal root ganglia (DRG) (A) and spinal cord (B) of male rats with monoiodoacetate (MIA)-induced osteoarthritis. L3-L5 ipsilateral DRGs and spinal cord cross sections were isolated 28 days after MIA/saline injection and mRNA expression of Il-1β, Tnf-α, Ngf, Bdnf and Tac1 was determined by quantitative real-time PCR. VOR/DLX was administered orally once daily for 28 days after MIA injection. Statistical significance was determined in comparison with the saline control group (#P < 0.05,##P < 0.01,###P < 0.01) or the MIA control group (*P < 0.05, **P < 0.01, ***P < 0.001) using one-way ANOVA followed by Tukeypost-hoc test. Data are plotted as mean ± SEM.