Figure 3. Treatment with vortioxetine (VOR)
and duloxetine (DLX) attenuated mechanical hypersensitivity in male (A)
and female (B) rats with monoiodoacetate (MIA)-induced knee
osteoarthritis. Results were presented as time course data of paw
withdrawal threshold (PWT) and area under the curve (AUC) obtained
during the 28 days of the experiment. VOR/DLX was administered orally
once daily for 28 days following MIA injection (indicated by arrows).
Statistical significance was determined in comparison with the saline
control group (###P < 0.001) or
the MIA control group (*P < 0.05, **P< 0.01, ***P < 0.001) using a two-way ANOVA
with repeated measures (time course data) or one-way ANOVA (AUC data)
followed by Tukey post-hoc test. Data are plotted as mean ± SEM
of PWT/AUC values.